Evidence map›Paper›PMID 32592491›Full record

ArticleSleep2021

Functional organization of the insula in men and women with obstructive sleep apnea during Valsalva.

Amrita Pal, Jennifer A Ogren, Andrea P Aguila, Ravi Aysola, Rajesh Kumar, Luke A Henderson, Ronald M Harper, Paul M Macey

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Amrita PalUCLA School of Nursing, University of California, Los Angeles, CA.
Jennifer A OgrenDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.
Andrea P AguilaUCLA School of Nursing, University of California, Los Angeles, CA.
Ravi AysolaDivision of Pulmonary and Critical Care, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.
Rajesh KumarDepartment of Anesthesiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.
Luke A HendersonDepartment of Anatomy and Histology, Sydney Medical School, University of Sydney, Sydney, Australia.
Ronald M HarperDepartment of Neurobiology, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA.
Paul M MaceyUCLA School of Nursing, University of California, Los Angeles, CA.
University of California, Los Angeles · USThe University of Sydney · AU

Funding

GABA and glutamate changes underlying altered autonomic function in obstructive sleep apneaR01HL135562 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M, THOMAS, MICHAEL ALBERT · 2018 to 2021
$2.9M
Sex-specific brain injury and symptoms in sleep apneaR56NR017435 · NINR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MACEY, PAUL M · 2018 to 2018
$300k
NHLBI NIH HHS R01 HL135562NINR NIH HHS R56 NR017435
6 · The paper itself

Abstract

STUDY

objectivesObstructive sleep apnea (OSA) patients show impaired autonomic regulation, perhaps related to functional reorganization of the insula, which in healthy individuals shows sex-specific anterior and right dominance during sympathetic activation. We examined insular organization of responses to a Valsalva maneuver in OSA with functional magnetic resonance imaging (fMRI).

methodsWe studied 43 newly diagnosed OSA (age mean ± SD: 46.8 ± 8.7 years; apnea-hypopnea index (AHI) ± SD: 32.1 ± 20.1 events/hour; 34 males) and 63 healthy (47.2 ± 8.8 years; 40 males) participants. Participants performed four 18-second Valsalva maneuvers (1-minute intervals, pressure ≥ 30 mmHg) during scanning. fMRI time trends from five insular gyri-anterior short (ASG); mid short (MSG); posterior short (PSG); anterior long (ALG); and posterior long (PLG)-were assessed for within-group responses and between-group differences with repeated measures ANOVA (p < 0.05); age and resting heart rate (HR) influences were also assessed.

resultsRight and anterior fMRI signal dominance appeared in OSA and controls, with no between-group differences. Separation by sex revealed group differences. Left ASG anterior signal dominance was lower in OSA versus control males. Left ASG and ALG anterior dominance was higher in OSA versus control females. In all right gyri, only OSA females showed greater anterior dominance than controls. Right dominance was apparent in PSG and ALG in all groups; females showed right dominance in MSG and PLG. OSA males did not show PLG right dominance. Responses were influenced substantially by HR but modestly by age.

conclusionsAnterior and right insular fMRI dominance appears similar in OSA versus control participants during the sympathetic phase of the Valsalva maneuver. OSA and control similarities were present in just males, but not necessarily females, which may reflect sex-specific neural injury.

Indexed as

Sleep Apnea, ObstructiveAdultAutonomic Nervous SystemCerebral CortexFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedValsalva Maneuverautonomic nervous systemblood pressurefMRI

Identifiers

PMID32592491
PMCPMC7819841
OpenAlexW3037083538

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.