Evidence map›Paper›PMID 32592530›Full record

SynthesisHuman brain mapping2020

A technical review of canonical correlation analysis for neuroscience applications.

Xiaowei Zhuang, Zhengshi Yang, Dietmar Cordes

Abstract readSystematic Review
In one paragraph

Synthesis in Human brain mapping, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
92citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

92 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Linking the exposome to the brain-behaviour phenotype.Nature reviews. Neuroscience · 2026
    Review
  7. Predicting pain location from resting-state brain fMRI.bioRxiv : the preprint server for biology · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Generative Principal Component Regression via Variational Inference.IEEE transactions on signal processing : a publication of the IEEE Signal Processing Society · 2026
    Article
  15. Article
  16. Multimodal Fusion of Structural and Diffusion MRI for Intelligence Prediction.Proceedings. IEEE Southwest Symposium on Image Analysis and Interpretation · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Cortical myelin mapping in antipsychotic medication-naïve, first-episode psychosis patients.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article

32 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Xiaowei ZhuangCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.ORCID 0000-0002-0581-6530
Zhengshi YangCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.ORCID 0000-0002-9796-9680
Dietmar CordesCleveland Clinic Lou Ruvo Center for Brain Health, Las Vegas, Nevada, USA.ORCID 0000-0001-6574-5546

Funding

Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - ResubmissionP20GM109025 · NIGMS · CLEVELAND CLINIC FOUNDATION · PI JESSICA KIRKLAND CALDWELL · 2015 to 2026
$22.8M
Improving the Detection of Activation in High Resolution fMRI using MultivariateR01EB014284 · NIBIB · TORONTO METROPOLITAN UNIVERSITY · PI CORDES, DIETMAR · 2013 to 2015
$750k
NIBIB NIH HHS R01 EB014284NIGMS NIH HHS P20 GM109025
6 · The paper itself

Abstract

Collecting comprehensive data sets of the same subject has become a standard in neuroscience research and uncovering multivariate relationships among collected data sets have gained significant attentions in recent years. Canonical correlation analysis (CCA) is one of the powerful multivariate tools to jointly investigate relationships among multiple data sets, which can uncover disease or environmental effects in various modalities simultaneously and characterize changes during development, aging, and disease progressions comprehensively. In the past 10 years, despite an increasing number of studies have utilized CCA in multivariate analysis, simple conventional CCA dominates these applications. Multiple CCA-variant techniques have been proposed to improve the model performance; however, the complicated multivariate formulations and not well-known capabilities have delayed their wide applications. Therefore, in this study, a comprehensive review of CCA and its variant techniques is provided. Detailed technical formulation with analytical and numerical solutions, current applications in neuroscience research, and advantages and limitations of each CCA-related technique are discussed. Finally, a general guideline in how to select the most appropriate CCA-related technique based on the properties of available data sets and particularly targeted neuroscience questions is provided.

Indexed as

Canonical Correlation AnalysisMachine LearningModels, TheoreticalBrainHumansImage Processing, Computer-AssistedNeuroimagingNeurosciencescanonical correlation analysismultivariate analysisneuroscience

Identifiers

PMID32592530
PMCPMC7416047

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.