ArticleBMC neurology2020
Prediction of deep vein thrombosis by ultrasonography and D-dimer in Asian patients with ischemic stroke.
Article in BMC neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Deep Vein Thrombosis Prevention in Acute Ischemic Stroke Patients with Lower Limb Paralysis: A Narrative Review.Journal of clinical medicine · 2026Review
- Temporal Profile of Stroke-Associated Pneumonia and Deep Vein Thrombosis after Stroke.Cerebrovascular diseases extra · 2026Article
- A nomogram for individualized prediction of calf muscular venous thrombosis in patients with acute ischemic stroke: a retrospective study.Thrombosis journal · 2025Article
- Treatment-Specific Risk Scales for Identifying High-Risk Patients With Poor Prognosis in Acute Ischemic Stroke: A Cohort Study From the National Neurological Medical Center of China.CNS neuroscience & therapeutics · 2025Article
- Clinical characteristics analysis of stroke patients with lower extremity deep venous thrombosis.Frontiers in neurology · 2025Article
- Recent Updates and Advances in the Association Between Vitamin D Deficiency and Risk of Thrombotic Disease.Nutrients · 2024Review
- Association between higher systemic immune inflammation index (SII) and deep vein thrombosis (DVT) in patients with aneurysmal subarachnoid hemorrhage (aSAH) after endovascular treatment.Neurosurgical review · 2023Article
- Risk factors for lower extremity deep vein thrombosis in acute stroke patients following endovascular thrombectomy: a retrospective cohort study.Frontiers in neurology · 2023Article
- Predictors of deep-vein thrombosis for acute stroke at admission to a rehabilitation unit: A retrospective study.Frontiers in neurology · 2023Article
- Effects of low molecular weight heparin combined with hyperbaric oxygen on neurologic function and coagulation factors in patients with intracranial venous thrombosis.American journal of translational research · 2022Article
- Incidence and Risk Factors of Lower-Extremity Deep Vein Thrombosis After Thrombolysis Among Patients with Acute Ischemic Stroke.Pharmacogenomics and personalized medicine · 2021Article
- The Role of Vitamin D in the Relationship Between Gender and Deep Vein Thrombosis Among Stroke Patients.Frontiers in nutrition · 2021Article
- Central nervous system as a target of novel coronavirus infections: Potential routes of entry and pathogenic mechanisms.Journal of biosciences · 2021Review
- Nomogram Prediction for Lower Extremity Deep Vein Thrombosis in Acute Ischemic Stroke Patients Receiving Thrombolytic Therapy.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisArticle
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5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundDeep vein thrombosis (DVT) is an important complication of ischemic stroke, although the incidence of DVT is regarded as being lower in Asian than in non-Asian patients. Here, we investigated the incidence and factors associated with DVT in Asian patients with ischemic stroke.
methodsAcute ischemic stroke patients received lower extremity ultrasonography (LEUS) to diagnose the presence of DVT. Clinical characteristics and laboratory results, including D-dimer level, were compared between patients with and without DVT. Independent risk factors for DVT were investigated using multivariable analysis. Similar analysis was performed to identify factors associated with elevated D-dimer level (> 0.5 mg/dl) in acute ischemic stroke patients.
resultsDuring the study period, 289 patients were enrolled, and 38 (13.1%) showed DVT. Female sex (OR = 2.579, 95% CI = 1.224-5.432; p = 0.013) and a high National Institutes of Health Stroke Scale (NIHSS) score (OR = 1.191 95% CI = 1.095-1.294; p = 0.005) were independently associated with the presence of DVT, although D-dimer level was not. Stroke mechanism, especially cardioembolic stroke (OR = 3.777, 95% CI = 1.532-9.313; p = 0.004; reference: large artery atherosclerosis), NIHSS score (OR = 1.087, 95% CI = 1.002-1.179; p = 0.001) and thrombolysis (OR = 12.360, 95% CI 2.456-62.213; p = 0.002) were independently associated with elevated abnormal D-dimer levels.
conclusionThe severity of ischemic stroke, but not the D-dimer level, was associated with the presence of DVT in Asian ischemic stroke patients. D-dimer level was influenced by the stroke mechanism. LEUS in patients with severe neurological deficit, rather than screening with D-dimer, may be more beneficial for diagnosing DVT in Asian patients with acute ischemic stroke.
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