Evidence map›Paper›PMID 32597753›Full record

ArticleeLife2020

The role of Rif1 in telomere length regulation is separable from its role in origin firing.

Calla B Shubin, Carol W Greider

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Calla B ShubinDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-4618-2722
Carol W GreiderDepartment of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, United States.ORCID 0000-0002-5494-8126
Johns Hopkins University · US

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI ALAN KEITH MEEKER · 1985 to 2026
$208.6M
BIOCHEMISTRY, CELLULAR AND MOLECULAR BIOLOGY PROGRAMT32GM007445 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI GREEN, RACHEL · 1985 to 2021
$24.1M
National Science Foundation DGE-1746891NCI NIH HHS P30 CA006973NIGMS NIH HHS T32 GM007445
6 · The paper itself

Abstract

To examine the established link between DNA replication and telomere length, we tested whether firing of telomeric origins would cause telomere lengthening. We found that

Indexed as

Replication OriginCell CycleCell Cycle ProteinsDNA-Binding ProteinsDNA ReplicationGene DosageGenome, FungalMutationProtein Phosphatase 1Protein Serine-Threonine KinasesRepressor ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTelomereTelomere-Binding ProteinsTelomere HomeostasisCDC7 protein, S cerevisiaeCell Cycle ProteinsDNA-Binding ProteinsMCM5 protein, S cerevisiaeProtein Phosphatase 1Protein Serine-Threonine KinasesRepressor ProteinsRIF1 protein, S cerevisiaeSaccharomyces cerevisiae ProteinsSld3 protein, S cerevisiaeTelomere-Binding ProteinschromosomesDNA replicationgene expressiongeneticsgenomicsorigin firingRif1S. cerevisiaeTelomeres

Identifiers

PMID32597753
PMCPMC7371424
OpenAlexW3037230825

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.