ArticleJournal of clinical lipidology
Quantile-specific heritability of high-density lipoproteins with implications for precision medicine.
Article in Journal of clinical lipidology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Quantile-Specific Heritability of Inflammatory and Oxidative Stress Biomarkers Linked to Cardiovascular Disease.Journal of inflammation research · 2022Article
- Quantile-specific heritability of monocyte chemoattractant protein-1, and relevance to rs1024611-disease interactions.Cytokine · 2022Article
- Quantile-Dependent Heritability of Glucose, Insulin, Proinsulin, Insulin Resistance, and Glycated Hemoglobin.Lifestyle genomics · 2022Article
- Quantile-specific heritability of 8-isoprostane and the modulating effects of smoking, alcohol, cardiovascular disease and diabetes on 8-isoprostane-gene interactions.Free radical biology & medicine · 2022Article
- Article
- Quantile-specific heritability of total cholesterol and its pharmacogenetic and nutrigenetic implications.International journal of cardiology · 2021Article
- Quantile-Dependent Expressivity and Gene-Lifestyle Interactions Involving High-Density Lipoprotein Cholesterol.Lifestyle genomics · 2021Review
- Quantile-dependent expressivity of serum C-reactive protein concentrations in family sets.PeerJ · 2021Article
- Quantile-Dependent Expressivity of Serum Uric Acid Concentrations.International journal of genomics · 2021Article
- Quantile-specific heritability of sibling leptin concentrations and its implications for gene-environment interactions.Scientific reports · 2020Article
- Quantile-Specific Heritability of Intakes of Alcohol but not Other Macronutrients.Behavior genetics · 2020Article
- Article
- Quantile-specific heritability of serum growth factor concentrations.Growth factors (Chur, Switzerland)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
backgroundWe have previously shown that the effect of a high-density lipoprotein (HDL) genetic risk score depends on whether the phenotype (HDL cholesterol) is high or low relative to its distribution (quantile-dependent expressivity).
objectiveEvidence for quantile-dependent expressivity was sought using a more inclusive genetic measure (quantile-specific heritability, h
methodsQuantile regression was used to test whether the offspring-parent (β
resultsHDL cholesterol heritability estimated from β
conclusionHDL cholesterol heritability increased with increasing percentile of the offspring's HDL distribution. Whereas precision medicine is based on the premise that genetic markers identify patients most likely to benefit from drugs and diet, quantile-dependent expressivity postulates that the strong signals from these genetic markers simply trace the heritability increase with increasing plasma HDL concentrations. Thus, quantile-dependent expressivity provides an alternative interpretation to these genotype-specific effects.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.