Evidence map›Paper›PMID 32604056›Full record

ArticleBlood cells, molecules & diseases2020

Effects of Eupalinilide E and UM171, alone and in combination on cytokine stimulated ex-vivo expansion of human cord blood hematopoietic stem cells.

Jing Zhang, Xinxin Huang, Bin Guo, Scott Cooper, Maegan L Capitano, Trevor C Johnson, Dionicio R Siegel, Hal E Broxmeyer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood cells, molecules & diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Ex Vivo Expansion and Homing of Human Cord Blood Hematopoietic Stem Cells.Advances in experimental medicine and biology · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Jing ZhangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America; Experimental Hematology and Biochemistry Lab, Beijing Institute of Radiation Medicine, AMMS, Beijing 100850, China; South China Research Center for Stem Cell & Regenerative Medicine, SCIB, Guangzhou 510005, China. Electronic address: static_1111@163.com.
Xinxin HuangDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America; Zhongshan-Xuhus Hospital and the Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China.
Bin GuoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America; Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Scott CooperDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America.
Maegan L CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America.
Trevor C JohnsonGilead Sciences, Inc., Foster City, CA 94404, United States of America.
Dionicio R SiegelSkaggs School of Pharmacology and Pharmaceutical Sciences, University of California, San Diego, La Jolla, CA 92093, United States of America.
Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202-5181, United States of America. Electronic address: hbroxmey@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineCenter for High Pressure Science & Technology Advanced Research · CNGilead Sciences (United States) · USUniversity of California, San Diego · US

Funding

Project-005U54DK106846 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Reuben Kapur, Karen Elizabeth Pollok · 2015 to 2026
$9.7M
REGULATION OF HEMATOPOIETIC CELL PRODUCTIONT32DK007519 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI KAPLAN, MARK H · 1986 to 2020
$7.1M
Controlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1M
DEK Regulation of Hematopoietic Stem Cell Renewal, Fate, and HematopoiesisR01DK109188 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E., MARKOVITZ, DAVID MICHAEL · 2016 to 2019
$2.0M
NHLBI NIH HHS R35 HL139599NIDDK NIH HHS R01 DK109188NIDDK NIH HHS T32 DK007519NIDDK NIH HHS U54 DK106846
6 · The paper itself

Abstract

Eupalinilide E was assessed for ex-vivo expansion activity on hematopoietic stem cells (HSCs) from human cord blood (CB) CD34

Indexed as

Hematopoietic Stem Cell TransplantationAnimalsAntigens, CD34Cell Culture TechniquesCell ProliferationCells, CulturedCytokinesFetal BloodHematopoietic Stem CellsHumansIndolesMiceMice, SCIDPyrimidinesSesquiterpenesAntigens, CD34Cytokineseupalinilide EIndolesPyrimidinesSesquiterpenesUM171 compoundEupalinilide EEx vivo expansionGlycolysisHematopoietic stem cellsUM171

Identifiers

PMID32604056
PMCPMC7942758
OpenAlexW3033935344

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.