Evidence map›Paper›PMID 32606422›Full record

SynthesisTranslational psychiatry2020

Multi-trait analysis for genome-wide association study of five psychiatric disorders.

Yulu Wu, Hongbao Cao, Ancha Baranova, Hailiang Huang, Sheng Li, Lei Cai, Shuquan Rao, Minhan Dai, Min Xie, Yikai Dou and 7 more

Erratum issuedOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Translational psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 133 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 14 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 14 syntheses or guidelines pooled it, 229 citations in OpenAlex.

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  17. Zebrafish frk Gene Knockout Shows Social Impairments Relevant to Autism and Delays Brain Development by Increasing Cell Proliferation.Autism research : official journal of the International Society for Autism Research · 2026
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 8 institutions in 3 countries.

Yulu Wu *Mental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Hongbao Cao *Department of Psychiatry, First Clinical Medical College/First Hospital of Shanxi Medical University, Taiyuan, China.
Ancha Baranova *School of Systems Biology, George Mason University (GMU), Fairfax, VA, USA.
Hailiang HuangAnalytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.
Sheng LiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 1954 Huashan Road, Xuhui, 200030, Shanghai, China.
Lei CaiBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 1954 Huashan Road, Xuhui, 200030, Shanghai, China.
Shuquan RaoSchool of Life Science and Engineering, Southwest Jiaotong University, Chengdu, China.
Minhan DaiMental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Min XieMental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Yikai DouMental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Qinjian HaoThe Center of Gerontology and Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan, China.ORCID http://orcid.org/0000-0002-6917-1751
Ling ZhuMental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Xiangrong ZhangDepartment of Geriatric Psychiatry, Nanjing Brain Hospital, Affiliated to Nanjing Medical University, Nanjing, China.
Yin YaoCollaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China.
Fuquan ZhangDepartment of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, 264 Guangzhou Road, Nanjing, China. zhangfq@njmu.edu.cn.ORCID http://orcid.org/0000-0003-3204-8191
Mingqing XuBio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiaotong University, 1954 Huashan Road, Xuhui, 200030, Shanghai, China. mingqingxu@gmail.com.
Qiang WangMental Health Center and Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University, Chengdu, Sichuan, China. wangqiang130@scu.edu.cn.ORCID http://orcid.org/0000-0002-3849-1349
Sichuan University · CNShanghai Jiao Tong University · CNNanjing Brain Hospital · CNBroad Institute · USFudan University · CNGeorge Mason University · USShanxi Medical University · CNSouthwest Jiaotong University · CN

Funding

National Natural Science Foundation of China (National Science Foundation of China) 81471364National Natural Science Foundation of China (National Science Foundation of China) 81771446
6 · The paper itself

Abstract

We conducted a cross-trait meta-analysis of genome-wide association study on schizophrenia (SCZ) (n = 65,967), bipolar disorder (BD) (n = 41,653), autism spectrum disorder (ASD) (n = 46,350), attention deficit hyperactivity disorder (ADHD) (n = 55,374), and depression (DEP) (n = 688,809). After the meta-analysis, the number of genomic loci increased from 14 to 19 in ADHD, from 3 to 10 in ASD, from 45 to 57 in DEP, from 8 to 54 in BD, and from 64 to 87 in SCZ. We observed significant enrichment of overlapping genes among different disorders and identified a panel of cross-disorder genes. A total of seven genes were found being commonly associated with four out of five psychiatric conditions, namely GABBR1, GLT8D1, HIST1H1B, HIST1H2BN, HIST1H4L, KCNB1, and DCC. The SORCS3 gene was highlighted due to the fact that it was involved in all the five conditions of study. Analysis of correlations unveiled the existence of two clusters of related psychiatric conditions, SCZ and BD that were separate from the other three traits, and formed another group. Our results may provide a new insight for genetic basis of the five psychiatric disorders.

Indexed as

Attention Deficit Disorder with HyperactivityAutism Spectrum DisorderBipolar DisorderSchizophreniaGenetic Predisposition to DiseaseGenome-Wide Association StudyHumans

Identifiers

PMID32606422
PMCPMC7326916
OpenAlexW3038944827

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.