Evidence map›Paper›PMID 32606989›Full record

ArticleClinical epidemiology2020

Subsequent Development of Epithelial Ovarian Cancer After Ovarian Surgery for Benign Ovarian Tumor: A Population-Based Cohort Study.

Chen-Yu Huang, Wen-Hsun Chang, Hsin-Yi Huang, Chao-Yu Guo, Yiing-Jenq Chou, Nicole Huang, Wen-Ling Lee, Peng-Hui Wang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epidemiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. To do one and to get more: Part I. Diabetes and bone.Journal of the Chinese Medical Association : JCMA · 2022
    Review
  3. Article
  4. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Chen-Yu HuangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan.
Wen-Hsun ChangDepartment of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan.
Hsin-Yi HuangBiostatics Task Force, Taipei Veterans General Hospital, Taipei, Taiwan.
Chao-Yu GuoInstitute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0002-9066-9933
Yiing-Jenq ChouInstitute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0002-6424-5977
Nicole HuangInstitute of Hospital and Health Care Administration, National Yang-Ming University, Taipei, Taiwan.
Wen-Ling LeeInstitute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.ORCID 0000-0003-4956-896X
Peng-Hui WangDepartment of Obstetrics and Gynecology, Taipei Veterans General Hospital, Taipei, Taiwan.ORCID 0000-0002-6048-8541
National Yang Ming Chiao Tung University · TWAsia Eastern University of Science and Technology · TWTaipei Veterans General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe goal of the current study is to determine the risk of subsequent development of epithelial ovarian cancer (EOC) in women after ovarian surgery for benign ovarian tumors. PATIENTS AND

methodsWe conducted the nationwide population-based historic cohort study using the National Health Insurance Research Database (NHIRD) of Taiwan. Eleven thousand six hundred twenty women who underwent ovarian surgery for ovarian benign diseases were analyzed. The collected data included age, types of ovarian surgery, medical history by Charlson comorbidity index (CCI), infertility (yes/no), pelvic inflammatory disease (PID) (yes/no), tubal ligation (yes/no), total/subtotal hysterectomy (TH/STH) (yes/no), and endometrioma (yes/no). We used the Kaplan-Meier method and the Log-rank test to evaluate the risk factors. Cox proportional hazard methods were used to evaluate risk factors for the subsequent development of EOC. Multivariate analysis using Cox stepwise forward regression was conducted for the covariate selected in univariate analysis. Hazard ratio (HR) and 95% confidence interval (CI) were calculated using the Wald test.

resultsSubsequent EOC incidence rate (IR, incidence per 10,000 person-years) of women after ovarian surgery for benign ovarian tumors was 2.98. Separating into four groups based on different age, IR of EOC was 1.57 (<30 years), 4.71 (30-39 years), 3.59 (40-49 years) and 0.94 (≥50 years), respectively. Univariate and multivariate analyses identified only high level of CCI (≥2 or more) as an independent risk factor for subsequent development of EOC in women after ovarian surgery for benign ovarian tumors (HR 59.17, 95% CI 7.50-466.80 in women with CCI level of 2 and HR 190.68, 95% CI 24.33-2494.19, in women with CCI level ≥3, respectively).

conclusionOur results, if confirmed, suggest that women with other comorbidities (CCI) should be well informed that they may have a higher risk of subsequent development of EOC when ovarian surgery is planned even though the final pathology showed a benign ovarian tumor.

Indexed as

benign ovarian tumorcohort studyepidemiologyepithelial ovarian cancerovarian surgeryrisk

Identifiers

PMID32606989
PMCPMC7308129
OpenAlexW3036236939

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.