Evidence map›Paper›PMID 32612155›Full record

ArticleScientific reports2020

FMRP Regulates the Nuclear Export of Adam9 and Psen1 mRNAs: Secondary Analysis of an N

Cara J Westmark, Bryan Maloney, Reid S Alisch, Deborah K Sokol, Debomoy K Lahiri

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 21 citations in OpenAlex.

  1. FMRP promotes gastric cancer progression via mJournal of translational medicine · 2026
    Article
  2. Article
  3. Review
  4. Article
  5. Ribosomes in RNA Granules Are Stalled on mRNA Sequences That Are Consensus Sites for FMRP Association.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  6. Article
  7. Article
  8. N6-methyladenosine and Neurological Diseases.Molecular neurobiology · 2022
    Review
  9. Article
  10. Review
  11. Regulatory Mechanisms of the RNA Modification mFrontiers in cellular neuroscience · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Cara J WestmarkDepartment of Neurology, University of Wisconsin-Madison, Madison, WI, USA. westmark@wisc.edu.
Bryan MaloneyDepartment of Psychiatry, Indiana Alzheimer Disease Center, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA.
Reid S AlischDepartment of Neurological Surgery, University of Wisconsin-Madison, Madison, WI, USA.
Deborah K SokolDepartment of Neurology, Indiana University School of Medicine, Indianapolis, IN, USA.
Debomoy K LahiriDepartment of Psychiatry, Indiana Alzheimer Disease Center, Stark Neuroscience Research Institute, Indiana University School of Medicine, Indianapolis, IN, USA. dlahiri@iupui.edu.
Indiana University – Purdue University Indianapolis · USIndiana University School of MedicineNeurological Surgery · USUniversity of Wisconsin–Madison · US

Funding

University of Wisconsin Institute for Clinical and Translational ResearchUL1TR002373 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI ELIZABETH S BURNSIDE, Allan R. Brasier · 2017 to 2026
$75.9M
Research Education ComponentP30AG010133 · NIA · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI SAYKIN, ANDREW J · 1991 to 2020
$37.3M
Neurobiological Role of MicroRNA in Alzheimer'sR01AG051086 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHIRI, DEBOMOY K · 2015 to 2019
$1.9M
Testing a Novel Approach to Solve the On-target, Off-site Effects of Alzheimer's DrugsR21AG056007 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHIRI, DEBOMOY K · 2019 to 2020
$435k
NCATS NIH HHS UL1 TR002373NIA NIH HHS P30 AG010133NIA NIH HHS R01 AG051086NIA NIH HHS R21 AG056007
6 · The paper itself

Abstract

Fragile X mental retardation protein (FMRP) binds to and regulates the translation of amyloid-β protein precursor (App) mRNA, but the detailed mechanism remains to be determined. Differential methylation of App mRNA could underlie FMRP binding, message localization and translation efficiency. We sought to determine the role of FMRP and N

Indexed as

Databases, Nucleic AcidActive Transport, Cell NucleusADAM ProteinsAdenosineAnimalsCell NucleusFragile X Messenger Ribonucleoprotein 1Membrane ProteinsMicePresenilin-1RNA, MessengerAdam9 protein, mouseADAM ProteinsAdenosineFmr1 protein, mouseFragile X Messenger Ribonucleoprotein 1Membrane ProteinsN-methyladenosinePresenilin-1presenilin 1, mouseRNA, Messenger

Identifiers

PMID32612155
PMCPMC7329887
OpenAlexW3039370404

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.