ArticleScientific reports2020
Limited influence of the microbiome on the transcriptional profile of female Aedes aegypti mosquitoes.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- Convergent enrichment of Gammaproteobacteria along Aedes aegypti development across different breeding sites.Animal microbiome · 2026Article
- Mosquito host background impacts microbiome-Zika virus interactions in field- and laboratory-reared Aedes aegypti.Animal microbiome · 2025Article
- Leveraging microbial ecology for mosquito-borne disease control.Trends in parasitology · 2025Review
- Reduced microbe abundance in an urban larval development container increases Aedes aegypti susceptibility to Zika virus.PLoS pathogens · 2025Article
- Environmental yeasts differentially impact the development and oviposition behavior of the Asian tiger mosquito Aedes albopictus.Microbiome · 2025Article
- The dynamics of the midgut microbiome inPNAS nexus · 2024Article
- Aedes aegypti gut transcriptomes respond differently to microbiome transplants from field-caught or laboratory-reared mosquitoes.Environmental microbiology · 2024Article
- Introducing an environmental microbiome to axenicApplied and environmental microbiology · 2023Article
- The influence of the larval microbiome on susceptibility to Zika virus is mosquito genotype-dependent.PLoS pathogens · 2023Article
- Review
- Anopheline mosquitoes are protected against parasite infection by tryptophan catabolism in gut microbiota.Nature microbiology · 2022Article
- A transcriptomic atlas ofeLife · 2022Article
- Microbial Composition in Larval Water Enhances Aedes aegypti Development but Reduces Transmissibility of Zika Virus.mSphere · 2021Article
- Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host-microbiota interactions.Nature communications · 2021Article
- The Axenic and Gnotobiotic Mosquito: Emerging Models for Microbiome Host Interactions.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The microbiome is an assemblage of microorganisms living in association with a multicellular host. Numerous studies have identified a role for the microbiome in host physiology, development, immunity, and behaviour. The generation of axenic (germ-free) and gnotobiotic model systems has been vital to dissecting the role of the microbiome in host biology. We have previously reported the generation of axenic Aedes aegypti mosquitoes, the primary vector of several human pathogenic viruses, including dengue virus and Zika virus. In order to better understand the influence of the microbiome on mosquitoes, we examined the transcriptomes of axenic and conventionally reared Ae. aegypti before and after a blood meal. Our results suggest that the microbiome has a much lower effect on the mosquito's gene expression than previously thought with only 170 genes influenced by the axenic state, while in contrast, blood meal status influenced 809 genes. The pattern of expression influenced by the microbiome is consistent with transient changes similar to infection rather than sweeping physiological changes. While the microbiome does seem to affect some pathways such as immune function and metabolism, our data suggest the microbiome is primarily serving a nutritional role in development with only minor effects in the adult.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.