Evidence map›Paper›PMID 32629878›Full record

ArticleJournal of clinical medicine2020

Mild Cognitive Impairment Subtypes and Type 2 Diabetes in Elderly Subjects.

Silvia Valenza, Lucia Paciaroni, Susy Paolini, Anna Rita Bonfigli, Mirko Di Rosa, Rosa Anna Rabini, Elena Tortato, Paolo Pelliccioni, Giuseppe Pelliccioni

Abstract read
In one paragraph

Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Silvia ValenzaNeurology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.
Lucia PaciaroniNeurology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.
Susy PaoliniNeurology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.
Anna Rita BonfigliScientific Direction, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.ORCID 0000-0002-9619-0181
Mirko Di RosaUnit of Geriatric Pharmacoepidemiology and Biostatistics, Italian National Research Center on Aging (IRCCS INRCA), 60124 Ancona, Italy.ORCID 0000-0002-1862-4159
Rosa Anna RabiniMetabolic Diseases and Diabetology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.
Elena TortatoMetabolic Diseases and Diabetology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.
Paolo PelliccioniEye Clinic, Polytechnic University of Marche, 60126 Ancona, Italy.ORCID 0000-0002-6024-0183
Giuseppe PelliccioniNeurology Department, Italian National Research Center on Aging (IRCCS INRCA), 60100 Ancona, Italy.ORCID 0000-0002-0377-9713

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundType 2 diabetes (T2D) is correlated to amnestic mild cognitive impairment (aMCI) and to non-amnestic mild cognitive impairment (naMCI). This study evaluated whether the T2D variable characterizes a peculiar cognitive profile in elderly patients. Moreover, it explores the association between glycated hemoglobin levels (HbA1c), T2D duration, insulin and oral hypoglycemic agent treatment, and cognition in elderly diabetic patients.

methodsDetailed neuropsychological battery was used to diagnose MCI subtypes. A total of 39 MCI subjects with T2D (T2D-MCI) and 37 MCI subjects without T2D (ND-MCI), matched for age, educational level, and Mini-Mental State Examination score, were included.

resultsND-MCI performed worse in memory and language domains than T2D-MCI. The amnestic subtype is more frequent among ND-MCI and non-amnestic subtype in T2D-MCI. In T2D-MCI, high HbA1c levels correlate with episodic memory (immediate recall) and T2D duration. Some indexes of episodic memory (immediate recall), attention, and visual-spatial ability correlate with insulin treatment.

conclusionsAn association between T2D and non-amnestic MCI is suggested. In the T2D-MCI group, significant associations between insulin treatment and memory (immediate recall), complex figure copy, and attention were found.

Indexed as

agingAlzheimer’s diseasecognitive functionsdementiamild cognitive impairmentneuropsychological testtype 2 diabetes

Identifiers

PMID32629878
PMCPMC7408775

What Socratic holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.