Evidence map›Paper›PMID 32630191›Full record

Trial reportNutrients2020

Acute Effects of Lixisenatide on Energy Intake in Healthy Subjects and Patients with Type 2 Diabetes: Relationship to Gastric Emptying and Intragastric Distribution.

Ryan Jalleh, Hung Pham, Chinmay S Marathe, Tongzhi Wu, Madeline D Buttfield, Seva Hatzinikolas, Charles H Malbert, Rachael S Rigda, Kylie Lange, Laurence G Trahair and 4 more

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Review
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Ryan JallehEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.
Hung PhamAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Chinmay S MaratheEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.
Tongzhi WuEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.ORCID 0000-0003-1656-9210
Madeline D ButtfieldSchool of Health Sciences, University of South Australia, Adelaide SA 5001, Australia.
Seva HatzinikolasAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Charles H MalbertAniscan, Institut National de la Rechercher Agronomique, 35590 Saint-Gilles, France.ORCID 0000-0002-0665-4545
Rachael S RigdaAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Kylie LangeAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Laurence G TrahairAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Christine Feinle-BissetAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.ORCID 0000-0001-6848-0125
Christopher K RaynerAdelaide Medical School, Centre of Research Excellence in Translating Nutritional Science to Good Health, The University of Adelaide, Adelaide SA 5000, Australia.
Michael HorowitzEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.
Karen L JonesEndocrine and Metabolic Unit, Royal Adelaide Hospital, Adelaide SA 5000, Australia.ORCID 0000-0002-1155-5816
Royal Adelaide Hospital · AUThe University of Adelaide · AUInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement · FRUniversity of South Australia · AU

Funding

Sanofi Aventis Australia LIXISL06486
6 · The paper itself

Abstract

Glucagon-like peptide-1 receptor agonists induce weight loss, which has been suggested to relate to the slowing of gastric emptying (GE). In health, energy intake (EI) is more strongly related to the content of the distal, than the total, stomach. We evaluated the effects of lixisenatide on GE, intragastric distribution, and subsequent EI in 15 healthy participants and 15 patients with type 2 diabetes (T2D). Participants ingested a 75-g glucose drink on two separate occasions, 30 min after lixisenatide (10 mcg) or placebo subcutaneously, in a randomised, double-blind, crossover design. GE and intragastric distribution were measured for 180 min followed by a buffet-style meal, where EI was quantified. Relationships of EI with total, proximal, and distal stomach content were assessed. In both groups, lixisenatide slowed GE markedly, with increased retention in both the proximal (

Indexed as

Glucagon-Like Peptide-1 Receptor AgonistsAgedBeveragesCross-Over StudiesDiabetes Mellitus, Type 2Double-Blind MethodEnergy IntakeFemaleGastric EmptyingGlucagon-Like Peptide-2 ReceptorGlucoseHumansHypoglycemic AgentsMaleMealsMiddle AgedGlucagon-Like Peptide-1 Receptor AgonistsGlucagon-Like Peptide-2 ReceptorGlucoseHypoglycemic AgentslixisenatidePeptidesPlacebosenergy intakeintragastric meal retentionlixisenatidetype 2 diabetes

Identifiers

PMID32630191
PMCPMC7400134
OpenAlexW3039207684

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.