Evidence map›Paper›PMID 32630532›Full record

ArticleMolecules (Basel, Switzerland)2020

The (+)-Brevipolide H Displays Anticancer Activity against Human Castration-Resistant Prostate Cancer: The Role of Oxidative Stress and Akt/mTOR/p70S6K-Dependent Pathways in G1 Checkpoint Arrest and Apoptosis.

Yi-Hua Sheng, Wohn-Jenn Leu, Ching-Nung Chen, Jui-Ling Hsu, Ying-Tung Liu, Lih-Ching Hsu, Duen-Ren Hou, Jih-Hwa Guh

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
  2. Strategies for the synthesis of brevipolides.Beilstein journal of organic chemistry · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yi-Hua ShengSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Wohn-Jenn LeuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Ching-Nung ChenDepartment of Chemistry, National Central University, No. 300 Jhong-Da Road, Jhong-li, Taoyuan 32001, Taiwan.
Jui-Ling HsuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Ying-Tung LiuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Lih-Ching HsuSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.
Duen-Ren HouDepartment of Chemistry, National Central University, No. 300 Jhong-Da Road, Jhong-li, Taoyuan 32001, Taiwan.ORCID 0000-0003-1072-2915
Jih-Hwa GuhSchool of Pharmacy, National Taiwan University, No.33, Linsen S. Rd., Zhongzheng Dist., Taipei 100, Taiwan.ORCID 0000-0002-6738-6054
National Taiwan University · TWNational Central University · TW

Funding

Ministry of Science and Technology, Taiwan MOST 107-2320-B-002-018-MY3 and MOST 106-2320-B-002 -005 -MY3
6 · The paper itself

Abstract

Because conventional chemotherapy is not sufficiently effective against prostate cancer, various examinations have been performed to identify anticancer activity of naturally occurring components and their mechanisms of action. The (+)-brevipolide H, an α-pyrone-based natural compound, induced potent and long-term anticancer effects in human castration-resistant prostate cancer (CRPC) PC-3 cells. Flow cytofluorometric analysis with propidium iodide staining showed (+)-brevipolide H-induced G1 arrest of cell cycle and subsequent apoptosis through induction of caspase cascades. Since Akt/mTOR pathway has been well substantiated in participating in cell cycle progression in G1 phase, its signaling and downstream regulators were examined. Consequently, (+)-brevipolide H inhibited the signaling pathway of Akt/mTOR/p70S6K. The c-Myc inhibition and downregulation of G1 phase cyclins were also attributed to (+)-brevipolide H action. Overexpression of myristoylated Akt significantly rescued mTOR/p70S6K and downstream signaling under (+)-brevipolide H treatment. ROS and Ca

Indexed as

ApoptosisG1 Phase Cell Cycle CheckpointsAntineoplastic Agents, PhytogenicBiomarkers, TumorCell ProliferationCyclopropanesGene Expression Regulation, NeoplasticHumansMaleMembrane Potential, MitochondrialOxidative StressProstatic Neoplasms, Castration-ResistantProto-Oncogene Proteins c-aktPyronesRibosomal Protein S6 Kinases, 70-kDaSignal TransductionAntineoplastic Agents, PhytogenicBiomarkers, Tumorbrevipolide HCyclopropanesMTOR protein, humanProto-Oncogene Proteins c-aktPyronesRibosomal Protein S6 Kinases, 70-kDaTOR Serine-Threonine KinasesAkt/mTOR/p70S6K-dependent pathway(+)-brevipolide HG1 checkpoint arrestmitochondrial dysfunctionoxidative stress

Identifiers

PMID32630532
PMCPMC7355498
OpenAlexW3038037540

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.