Evidence map›Paper›PMID 32632526›Full record

SynthesisDiabetologia2020

A systematic review of trends in all-cause mortality among people with diabetes.

Lei Chen, Rakibul M Islam, Joanna Wang, Thomas R Hird, Meda E Pavkov, Edward W Gregg, Agus Salim, Maryam Tabesh, Digsu N Koye, Jessica L Harding and 4 more

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Diabetologia, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 70 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Type 2 diabetes mellitus.Nature reviews. Disease primers · 2026
    Review
  6. Metformin Beyond Glycemic Control: Cardiovascular Protection and Diabetes Prevention.Journal of cardiovascular development and disease · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Mechanisms of Xuefu Zhuyu decoction in treating diabetic kidney disease-induced renal fibrosis: UPLC-Q/TOF-MS, network pharmacology, and experimental validation.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2025
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 3 countries.

Lei ChenBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.ORCID 0000-0002-6581-0544
Rakibul M IslamSchool of Public Health and Preventive Medicine, Monash University, Melbourne, VIC, Australia.
Joanna WangBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Thomas R HirdBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Meda E PavkovDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Edward W GreggDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK.
Agus SalimBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Maryam TabeshBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Digsu N KoyeBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Jessica L HardingDivision of Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, GA, USA.
Julian W SacreBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Elizabeth L M BarrBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Dianna J MaglianoBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia. Dianna.Magliano@baker.edu.au.ORCID 0000-0002-9507-6096
Jonathan E ShawBaker Heart and Diabetes Institute, 75 Commercial Road, Melbourne, VIC, 3004, Australia.
Baker Heart and Diabetes Institute · AUCenters for Disease Control and Prevention · USImperial College London · GBMonash University · AU

Funding

Intramural CDC HHS CC999999
6 · The paper itself

Abstract

aims/hypothesisWe examined all-cause mortality trends in people with diabetes and compared them with trends among people without diabetes.

methodsMEDLINE, EMBASE and CINAHL databases were searched for observational studies published from 1980 to 2019 reporting all-cause mortality rates across ≥2 time periods in people with diabetes. Mortality trends were examined by ethnicity, age and sex within comparable calendar periods.

resultsOf 30,295 abstracts screened, 35 studies were included, providing data on 69 separate ethnic-specific or sex-specific populations with diabetes since 1970. Overall, 43% (3/7), 53% (10/19) and 74% (32/43) of the populations studied had decreasing trends in all-cause mortality rates in people with diabetes in 1970-1989, 1990-1999 and 2000-2016, respectively. In 1990-1999 and 2000-2016, mortality rates declined in 75% (9/12) and 78% (28/36) of predominantly Europid populations, and in 14% (1/7) and 57% (4/7) of non-Europid populations, respectively. In 2000-2016, mortality rates declined in 33% (4/12), 65% (11/17), 88% (7/8) and 76% (16/21) of populations aged <40, 40-54, 55-69 and ≥70 years, respectively. Among the 33 populations with separate mortality data for those with and without diabetes, 60% (6/10) of the populations with diabetes in 1990-1999 and 58% (11/19) in 2000-2016 had an annual reduction in mortality rates that was similar to or greater than in those without diabetes. CONCLUSIONS/

interpretationAll-cause mortality has declined in the majority of predominantly Europid populations with diabetes since 2000, and the magnitude of annual mortality reduction matched or exceeded that observed in people without diabetes in nearly 60% of populations. Patterns of diabetes mortality remain uncertain in younger age groups and non-Europid populations. REGISTRATION: PROSPERO registration ID CRD42019095974. Graphical abstract.

Indexed as

Diabetes MellitusAustraliaCanadaCause of DeathEthnicityEuropeHumansMortalityRepublic of KoreaTaiwanUnited StatesDiabetesEpidemiologyMortalitySystematic reviewTrends

Identifiers

PMID32632526
PMCPMC11000245
OpenAlexW3040486209

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.