Evidence map›Paper›PMID 32634285›Full record

ArticleJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research2020

CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH.

Gexin Zhao, Elliot W Kim, Jie Jiang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, John S Adams, Sotirios Tetradis, Karen M Lyons

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Bone matrix proteins: regulators of skeletal remodeling and repair.Journal of bone and mineral metabolism · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Gexin ZhaoDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Elliot W KimDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Jie JiangOrthopaedic Institution for Children Foundation, Hemophilia Treatment Center, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-6619-1936
Chimay BhootDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Kemberly R CharlesDepartment of Molecular Cell and Developmental Biology, University of California, Los Angeles, Los Angeles, CA, USA.
Jongseung BaekDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Subburaman MohanMusculoskeletal Disease Center, VA Loma Linda Healthcare Systems, Loma Linda, CA, USA.ORCID 0000-0003-0063-986X
John S AdamsDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.
Sotirios TetradisSchool of Dentistry, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-0157-1855
Karen M LyonsDepartment of Orthopaedic Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0001-9420-5813
University of California, Los Angeles · USOrthopaedic Institute for Children · USVA Loma Linda Healthcare System · US

Funding

Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
CCN PROTEINS IN CARTILAGE FORMATION AND MAINTENANCER01AR052686 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LYONS, KAREN M. · 2005 to 2015
$3.9M
GP130/STAT3 signalling in articular cartilage development and regenerationR01AR071734 · NIAMS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI EVSEENKO, DENIS, LYONS, KAREN M. · 2018 to 2022
$3.0M
Role and Mechanism of Claudin-11 Action and Signaling in BoneR01AR070806 · NIAMS · LOMA LINDA VETERANS ASSN RESEARCH & EDUC · PI MOHAN, SUBBURAMAN · 2017 to 2023
$1.6M
BLRD VA IK6 BX005381NIAMS NIH HHS R01 AR052686NIAMS NIH HHS R01 AR070806NIAMS NIH HHS R01 AR071734NIAMS NIH HHS R21 AR071734NIAMS NIH HHS T32 AR059033NIAMS NIH HHS T32AR059033
6 · The paper itself

Abstract

CCN1/Cyr61 is a dynamically expressed matricellular protein that serves regulatory functions in multiple tissues. Previous studies from our laboratory demonstrated that CCN1 regulates bone maintenance. Using an osteoblast and osteocyte conditional knockout mouse model (Ccn1

Indexed as

Mechanotransduction, CellularParathyroid HormoneAnimalsCysteine-Rich Protein 61MiceOsteoblastsReceptor, Parathyroid Hormone, Type 1Wnt Signaling PathwayCCN1 protein, mouseCysteine-Rich Protein 61Parathyroid HormoneReceptor, Parathyroid Hormone, Type 1CCN1/CYR61INTEGRINMECHANOTRANSDUCTIONOSTEOBLASTSPTHPTH1R

Identifiers

PMID32634285
PMCPMC9361511
OpenAlexW3040017686

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.