Evidence map›Paper›PMID 32635638›Full record

ArticleInternational journal of molecular sciences2020

Aspirin Induces Mitochondrial Ca

Itsuho Fujikawa, Takashi Ando, Manami Suzuki-Karasaki, Miki Suzuki-Karasaki, Toyoko Ochiai, Yoshihiro Suzuki-Karasaki

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Aspirin Combined with Antifungal Drugs SuppressesJournal of microbiology and biotechnology · 2025
    Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Protective Effect ofMolecules (Basel, Switzerland) · 2023
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Itsuho FujikawaDepartment of Dermatology, Nihon University Hospital, Tokyo 101-830, Japan.ORCID 0000-0002-3026-3878
Takashi AndoDepartment of Orthopedic Surgery, Yamanashi University School of Medicine, Yamanashi 409-3898, Japan.
Manami Suzuki-KarasakiPlasma ChemiBio Laboratory, Nasushiobara, Tochigi 329-2813, Japan.
Miki Suzuki-KarasakiPlasma ChemiBio Laboratory, Nasushiobara, Tochigi 329-2813, Japan.
Toyoko OchiaiDepartment of Dermatology, Nihon University Hospital, Tokyo 101-830, Japan.
Yoshihiro Suzuki-KarasakiPlasma ChemiBio Laboratory, Nasushiobara, Tochigi 329-2813, Japan.
Nihon University · JPUniversity of Yamanashi · JP

Funding

Japan Society for the Promotion of Science 15K09792Japan Society for the Promotion of Science 18K09121
6 · The paper itself

Abstract

Aspirin (acetylsalicylic acid) and its metabolite salicylate, have an anti-melanoma effect by evoking mitochondrial dysfunction through poorly understood mechanisms. Depolarization of the plasma membrane potential leads to voltage-gated Ca

Indexed as

Anti-Inflammatory Agents, Non-SteroidalAspirinCalciumCalcium Channels, L-TypeCell Line, TumorCell SurvivalDrug Screening Assays, AntitumorHumansMelanomaMitochondriaAnti-Inflammatory Agents, Non-SteroidalAspirinCACNA1C protein, humanCalciumCalcium Channels, L-Typeapoptosisaspirindepolarizationl-type Ca2+ channelmelanomamitochondriasalicylatevoltage-gated Ca2+ entry

Identifiers

PMID32635638
PMCPMC7370041
OpenAlexW3040395581

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.