Evidence map›Paper›PMID 32637725›Full record

ArticleContemporary clinical trials communications2020

Nitrous oxide as a putative novel dual-mechanism treatment for bipolar depression: Proof-of-concept study design and methodology.

Mikaela K Dimick, Danielle Omrin, Bradley J MacIntosh, Rachel H B Mitchell, Daniel Riegert, Anthony Levitt, Ayal Schaffer, Susan Belo, John Iazzetta, Garfield Detzler and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02351869 (Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder), which is not on this map. Cited by 3 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02351869 phase2terminatednot on this map

Nitrous Oxide as a Putative Novel Dual-Mechanism Treatment for Bipolar Disorder

TypeinterventionalSponsorSunnybrook Health Sciences CentreRan2015 to 2020Enrolled25ConditionsBipolar DisorderArmsNitrous Oxide, Midazolam
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Mikaela K DimickPharmacology and Toxicology Department, University of Toronto, Toronto, Ontario, Canada.
Danielle OmrinSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Bradley J MacIntoshSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Rachel H B MitchellSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Daniel RiegertSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Anthony LevittSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Ayal SchafferSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Susan BeloSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
John IazzettaSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Garfield DetzlerSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Mabel ChoiSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Stephen ChoiSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Beverley A OrserSunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Benjamin I GoldsteinPharmacology and Toxicology Department, University of Toronto, Toronto, Ontario, Canada.
Sunnybrook Health Science Centre · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDepressive symptoms predominate in the course of bipolar disorder (BD) and there is an urgent need to evaluate novel application of repurposed compounds that act on pre-specified treatment targets. Several lines of reasoning suggest that nitrous oxide (N

methodsParticipants with BD-I/-II currently experiencing a major depressive episode will be randomized to one of two conditions (n = 20/group): 1) inhaled N

conclusionsN

Indexed as

Bipolar depressionCerebral blood flowNitrous oxideNovel therapeutics

Identifiers

PMID32637725
PMCPMC7327241
OpenAlexW3037635244

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.