ReviewHormones (Athens, Greece)2021
Graves' hyperthyroidism-related pancytopenia: a case report with literature review.
Review in Hormones (Athens, Greece), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Clinical characteristics of antithyroid drug-induced aplastic anemia cases over the past 30 years.Frontiers in endocrinology · 2023Pooled it
- Rare Autoimmune Pancytopenia Due to Graves Disease.JCEM case reports · 2025Article
- Evaluation of Etiological Causes and Incidence of Pancytopenia: A Case Series from a Tertiary Care Center.Cureus · 2025Article
- Methimazole-Induced Pancytopenia in a Patient with Graves' Disease: A Case Report and Literature Review.Current drug safety · 2025Review
- Sepsis-induced Pancytopenia in an Adolescent Girl with Thyroid Storm: A Case ReportJournal of clinical research in pediatric endocrinology · 2024Article
- Hyperthyroidism crisis and complex pancytopenia: A case report.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024Article
- A young patient with Graves' disease presenting with a triad of heart failure, pancytopenia, and jaundice: A case report.Clinical case reports · 2024Article
- Graves' disease with pancytopenia: A rare case report.Clinical case reports · 2024Article
- Therapeutic plasma exchange for Graves' disease in pregnancy.Obstetric medicine · 2023Article
- A 30-Year-Old Woman with a History of Autoimmune Hyperthyroidism Presenting with Fever and Oral Ulcers, Diagnosed with Discoid Lupus Erythematosus.The American journal of case reports · 2023Article
- [Adverse reactions of methimazole in children with hyperthyroidism].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOccurrence of pancytopenia in patients with untreated hyperthyroidism is extremely rare. To the best of our knowledge, only 30 cases have been reported in the English literature. Accurate diagnosis and appropriate tailored therapy are challenging due to the variegated causes of pancytopenia and the potential hematological toxicity of antithyroid drugs (ATDs). CASE REPORT: We present a 51-year-old Caucasian man with newly diagnosed Graves' disease showing pancytopenia and liver dysfunction. Although in this context the use of ATDs is still under debate, low-dose methimazole therapy was able to induce resolution of both pancytopenia and liver dysfunction, along with euthyroidism restoration.
conclusionSearching in the English literature for previous studies, we identified only 30 cases worldwide to form our database. A demographic as well as clinical, laboratory, and histopathological analysis was performed. In most cases, the recovery of biochemical euthyroidism through the use of ATDs induced the resolution of pancytopenia (at laboratory and histological levels). Our review provides clinical, laboratory, and histopathological features of Graves's hyperthyroidism-related pancytopenia with a view to improving the knowledge of this rare hematological complication and assisting in the decision-making process regarding therapeutic options.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.