Evidence map›Paper›PMID 32641122›Full record

ArticleBMC medical genomics2020

Genome-wide identification of methylated CpG sites in nongenital cutaneous warts.

Laith N Al-Eitan, Mansour A Alghamdi, Amneh H Tarkhan, Firas A Al-Qarqaz

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC medical genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Guideline
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Laith N Al-EitanDepartment of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan. lneitan@just.edu.jo.ORCID 0000-0003-0064-0190
Mansour A AlghamdiDepartment of Anatomy, College of Medicine, King Khalid University, Abha, 61421, Saudi Arabia.
Amneh H TarkhanDepartment of Applied Biological Sciences, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Firas A Al-QarqazDepartment of Internal Medicine, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Jordan University of Science and Technology · JOKing Khalid University · SA

Funding

Jordan University of Science and Technology 177/2017
6 · The paper itself

Abstract

backgroundLow-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital cutaneous warts.

methodsGenomic DNA was extracted from 24 paired epidermal samples of warts and normal skin. DNA samples were bisulfite converted and underwent genome-wide methylation profiling using the Infinium MethylationEPIC BeadChip Kit.

resultsFrom a total of 844,234 CpG sites, 56,960 and 43,040 CpG sites were found to be hypo- and hypermethylated, respectively, in non-genital cutaneous warts. The most differentially methylated CpG sites in warts were located within the C10orf26, FAM83H-AS1, ZNF644, LINC00702, GSAP, STAT5A, HDAC4, NCALD, and EXOC4 genes.

conclusionNon-genital cutaneous warts exhibit a unique CpG methylation signature.

Indexed as

CpG IslandsDNA MethylationEpigenesis, GeneticGenome, HumanFemaleHumansMalePromoter Regions, GeneticSkin DiseasesWartsCpGDNA methylationEpigeneticsHPVWarts

Identifiers

PMID32641122
PMCPMC7346436
OpenAlexW3041041105

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.