ReviewBiomedicines2020
The Link between Chronic Stress and Accelerated Aging.
Review in Biomedicines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07334106 (Emotional Well-being and Biomarkers of Healthy Aging), which is not on this map. Cited by 89 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Emotional Well-being and Biomarkers of Healthy Aging
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- In vivo quantitative imaging of hippocampal inflammation in autoimmune neuroinflammatory conditions: a systematic review.Clinical and experimental immunology · 2022Pooled it
- Influence of Age and Dose on the Effect of Resveratrol for Glycemic Control in Type 2 Diabetes Mellitus: Systematic Review and Meta-Analysis.Molecules (Basel, Switzerland) · 2022Pooled it
- "Where-There-Is-No-Psychiatrist Integrated Personal Therapy" among Community-Dwelling Older Adults: A Randomized Pilot Study.International journal of environmental research and public health · 2021Trial
- Work stress and healthy aging: A conceptual framework for the Semmelweis study and the Semmelweis-EUniWell workplace health promotion model program.GeroScience · 2026Review
- Corticosterone Concentration Varies With Metabolic Rate in Vertebrates.Ecology and evolution · 2026Article
- Psychological Distress and Biological Stress Markers After Spinal Cord Injury: A Longitudinal Multi-Omics Pilot Study.International journal of molecular sciences · 2026Article
- Silymarin reverses post-traumatic stress-induced memory impairment in mice by containment of oxidative stress, cholinergic dysfunction, and modulation of neuronal caspase-3 expression.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Traumatic life experiences during critical periods lead to diverse developmental trajectories.Cell reports. Medicine · 2026Article
- Article
- Article
- Comparative Evaluation of Different Fruit Parts ofFoods (Basel, Switzerland) · 2026Article
- Article
- Stimulated cytokine production, attachment, and emotional well-being in dementia spousal caregivers.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026Article
- Chronic stress antagonizes formation of stress granules.iScience · 2026Article
- The impact of the six pillars of lifestyle medicine on the biology of skin aging.Frontiers in aging · 2026Review
- Molecular pathways linking chronic psychological stress to accelerated aging: mechanisms and interventions.Frontiers in aging · 2026Review
- GPCR systems coordinate cellular resilience against aging-associated stress.Frontiers in molecular biosciences · 2026Review
- Association between long-term healthy aging trajectories and all-cause mortality among middle-aged and older adults.Archives of public health = Archives belges de sante publique · 2025Article
- The dynamics of stress experiences of students with relatives with addiction problems: a longitudinal qualitative study.European journal of psychotraumatology · 2025Article
- Differential role of anterior and posterior pituitary lobes in healthy aging and perceived stress.Scientific reports · 2025Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
People exposed to chronic stress age rapidly. The telomeres in their cells of all types shorten faster. Inflammation is another important feature of stress that, along with aging, accounts for the phenomenon of inflammaging. In addition to aging itself, inflammaging can contribute to the development of several pathologies, including atherosclerosis, diabetes, hypertension, and others. Oxidative stress is one of the main mechanisms related to stress. Oxidative stress is caused by the over-production of reactive oxygen species (ROS) that can damage various tissues. The main source of ROS is mitochondria. Being suppressed by mitochondrial mutations, mitophagy can aggravate the situation. In this case, the aging-specific pro-inflammatory changes are amplified. It happens because of the inability of cells to maintain the normal state of mitochondria. Macrophages are the crucial element of the innate immunity associated with the chronic inflammation and, subsequently, with the inflammaging. In this review, we focus on the therapy approaches potentially reducing the deleterious effects of oxidative stress. These include stimulation of mitophagy, activation of mitochondrial uncoupling, induction of the expression of the telomerase catalytic component gene, and use of antioxidants. Any method reducing oxidative stress should improve post-traumatic stress disorder.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.