ArticleSkeletal muscle2020
Exercise promotes satellite cell contribution to myofibers in a load-dependent manner.
Article in Skeletal muscle, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
50 citing papers in PubMed, 82 citations in OpenAlex.
- Low-load blood flow-restricted resistance exercise produces fiber type-independent hypertrophy and improves muscle functional capacity in older individuals.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- PAX3-SIX2 muscle stem cell heterogeneity drives muscle-specific repair dynamics diversification.Science advances · 2026Article
- MBNL depletion drives stem cell fusion and immature myonuclear states in myotonic dystrophy type 1.Nature communications · 2026Article
- Progress on cell therapy for skeletal muscle disorders.Advanced drug delivery reviews · 2026Review
- Glutamine-driven reductive TCA cycle metabolism supports aged muscle stem cell function via de novo lipogenesis.Nature aging · 2026Article
- The contribution of skeletal muscle interstitial cells to myogenesis.Skeletal muscle · 2026Review
- Non-regenerative myogenesis in adult skeletal muscles: myofiber death-independent muscle satellite cell expansion.Skeletal muscle · 2026Review
- Endocrine control of skeletal muscle regeneration and clinical applications.Nature reviews. Endocrinology · 2026Article
- Calcitonin receptor downregulation and exercise-conditioned blood enable systemic muscle stem cell proliferation.Nature communications · 2025Article
- Skeletal muscle endothelial dysfunction through the activin A-PGC1α axis drives progression of cancer cachexia.Nature cancer · 2025Article
- Is physical fitness associated with leucocyte telomere length in youth with type 1 diabetes?Pediatric research · 2025Article
- PoWeR elicits intracellular signaling, mitochondrial adaptations, and hypertrophy in multiple muscles consistent with endurance and resistance exercise training.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Neuromuscular electrical stimulation training induces myonuclear accretion and hypertrophy in mice without overt signs of muscle damage and regeneration.Skeletal muscle · 2025Article
- Extracellular fluid volume as a key indicator in home-care management of chronic heart failure: The role of nutritional and exercise therapy.Clinical case reports · 2024Article
- Exercise and nutrition benefit skeletal muscle: From influence factor and intervention strategy to molecular mechanism.Sports medicine and health science · 2024Review
- Lineage tracing of nuclei in skeletal myofibers uncovers distinct transcripts and interplay between myonuclear populations.Nature communications · 2024Article
- Decreased number of satellite cells-derived myonuclei in both fast- and slow-twitch muscles in HeyL-KO mice during voluntary running exercise.Skeletal muscle · 2024Article
- Integrative effects of resistance training and endurance training on mitochondrial remodeling in skeletal muscle.European journal of applied physiology · 2024Review
- Satellite cell-derived TRIM28 is pivotal for mechanical load- and injury-induced myogenesis.EMBO reports · 2024Article
- Targeted expression of heme oxygenase-1 in satellite cells improves skeletal muscle pathology in dystrophic mice.Skeletal muscle · 2024Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSatellite cells (SCs) are required for muscle repair following injury and are involved in muscle remodeling upon muscular contractions. Exercise stimulates SC accumulation and myonuclear accretion. To what extent exercise training at different mechanical loads drive SC contribution to myonuclei however is unknown.
resultsBy performing SC fate tracing experiments, we show that 8 weeks of voluntary wheel running increased SC contribution to myofibers in mouse plantar flexor muscles in a load-dependent, but fiber type-independent manner. Increased SC fusion however was not exclusively linked to muscle hypertrophy as wheel running without external load substantially increased SC fusion in the absence of fiber hypertrophy. Due to nuclear propagation, nuclear fluorescent fate tracing mouse models were inadequate to quantify SC contribution to myonuclei. Ultimately, by performing fate tracing at the DNA level, we show that SC contribution mirrors myonuclear accretion during exercise.
conclusionsCollectively, mechanical load during exercise independently promotes SC contribution to existing myofibers. Also, due to propagation of nuclear fluorescent reporter proteins, our data warrant caution for the use of existing reporter mouse models for the quantitative evaluation of satellite cell contribution to myonuclei.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.