Evidence map›Paper›PMID 32647922›Full record

SynthesisClinical neuroradiology2021

Embolic Stroke of Undetermined Source and Carotid Intraplaque Hemorrhage on MRI : A Systemic Review and Meta-Analysis.

Ian T Mark, Deena M Nasr, John Huston, Lucio de Maria, Paolo de Sanctis, Vance T Lehman, Alejandro A Rabinstein, Luca Saba, Waleed Brinjikji

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Clinical neuroradiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Vessel Wall Imaging in Cryptogenic Stroke.Radiologic clinics of North America · 2023
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Association of Carotid Plaque Calcification Attenuation With Intraplaque Hemorrhage Volume: 3D-Segmentation Analysis.Journal of neuroimaging : official journal of the American Society of Neuroimaging
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Ian T MarkDepartment of Radiology, Mayo Clinic, 200 1st St. SW, 55905, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-4036-2992
Deena M NasrDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
John HustonDepartment of Radiology, Mayo Clinic, 200 1st St. SW, 55905, Rochester, MN, USA.
Lucio de MariaDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Paolo de SanctisDepartment of Neurosurgery, Mayo Clinic, Rochester, MN, USA.
Vance T LehmanDepartment of Radiology, Mayo Clinic, 200 1st St. SW, 55905, Rochester, MN, USA.
Alejandro A RabinsteinDepartment of Neurology, Mayo Clinic, Rochester, MN, USA.
Luca SabaDepartment of Radiology, University of Cagliari, Cagliari, Italy.
Waleed BrinjikjiDepartment of Radiology, Mayo Clinic, 200 1st St. SW, 55905, Rochester, MN, USA. brinjikji.waleed@mayo.edu.
Mayo Clinic · USMayo Clinic in Arizona · USUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmbolic stroke of undetermined source (ESUS) has traditionally discounted the significance of internal carotid artery stenosis of <50%; however, recent studies have examined the role of carotid artery intraplaque hemorrhage (IPH) as an etiology in nonstenotic carotid arteries. We performed a systemic review of the literature to determine the prevalence of carotid artery IPH on magnetic resonance imaging (MRI) of the vessel wall in patients with ESUS.

methodsWe used PubMed, Epub ahead of print, Ovid MEDLINE in-process and other non-indexed citations, Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane central register of controlled trials, Ovid Cochrane database of systematic reviews and Scopus. Our study consisted of all case series with >10 patients with IPH and ESUS published through October 2018. Additionally, we included 123 patients from an institutional database from 2015-2019. Random effects meta-analysis was used for pooling across studies. Meta-analysis results were expressed as odds ratio (OR) with respective 95% confidence intervals (CI).

resultsA total of 7 studies with 354 patients were included. The mean age was 67.5 years old. The overall prevalence estimate for prevalence of IPH ipsilateral to the ischemic lesion was 25.8% (95% CI 13.1-38.5). The odds of having IPH on the ipsilateral side versus the contralateral side was 6.92 (95% CI 3.04-15.79).

conclusionPatients with ESUS have IPH in the carotid artery ipsilateral to the ischemic stroke in 25.8% of cases. Carotid artery vessel wall MRI should be considered as part of the standard work-up in patients with ESUS.

Indexed as

Carotid StenosisEmbolic StrokePlaque, AtheroscleroticStrokeAgedCarotid ArteriesHemorrhageHumansMagnetic Resonance ImagingRisk FactorsCarotid arteryCase seriesIschemiaMagnetic resonance imagingStenosis

Identifiers

PMID32647922
OpenAlexW3041107871

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.