ReviewCurrent cardiology reports2020
Left Ventricular Noncompaction Syndrome: Genetic Insights and Therapeutic Perspectives.
Review in Current cardiology reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 27 citations in OpenAlex.
- LAD/BSA and NT-proBNP as predictors of cardiovascular death in pediatric left ventricular non-compaction: a multicenter longitudinal cohort study.Pediatric research · 2026Article
- Clinical phenotypes across age groups and the predictive value of NT-proBNP for ventricular arrhythmias in left ventricular non-compaction: a multicenter cohort study.Journal of translational medicine · 2026Article
- Predictors of life-threatening events in adult patients with left ventricular noncompaction.World journal of cardiology · 2025Article
- A whole-exome sequencing study of patent foramen ovale: investigating genetic variants and their association with cardiovascular disorders.Frontiers in genetics · 2024Article
- Article
- Aortic root replacement for aortic root aneurysm with severe aortic regurgitation and incidentally detected left ventricular hyper-trabeculation/noncompaction.Indian journal of thoracic and cardiovascular surgery · 2022Article
- Successful pregnancy in left ventricular hypertrabeculation/noncompaction with implanted cardioverter/defibrillator and a variant in the TPM1 Gen (c.425A > T) in mother and child.Journal of cardiology cases · 2022Article
- Article
- Pathophysiology of Non-compaction Remains Enigmatic.Anatolian journal of cardiology · 2022Article
- Anticoagulation in cardiomyopathy: unravelling the hidden threat and challenging the threat individually.ESC heart failure · 2021Review
- Molecular Diagnosis of Inherited Cardiac Diseases in the Era of Next-Generation Sequencing: A Single Center's Experience Over 5 Years.Molecular diagnosis & therapy · 2021Article
- Cardiac disease in mitochondrial disorders.Heart failure reviews · 2021Article
- Myotonic dystrophy patients: More data about cardiac and neurologic findings would be useful.ESC heart failure · 2021Article
- Multisystem disease including stroke, epilepsy, dystonia, noncompaction, and kidney agenesis requires genetic work-up.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewTo discuss the association of left ventricular hypertrabeculation/noncompaction (LVHT/LVNC/NCCM) with genetic disease and to outline the therapeutic options for non-symptomatic and symptomatic LVHT. RECENT
findingsA number of new mutated genes have been recently detected being associated with LVHT. There are indications that microtubules changing cell polarity, the transcription factor Nkx2-5, and NOTCH-1 signaling are involved in the pathogenesis of LVHT. There are also indications that the PKC signaling pathway, which is involved in the regulation of gap junction intercellular communication, is disturbed in LVHT. LVHT is the same as LVNC and is associated with pathogenic variants in > 110 mtDNA or nDNA genes. LVHT has been also reported in > 15 chromosomal defects. However, a causal relation between any of these variants and LVHT has not been proven. There is no general agreement on the treatment of LVHT. According to expert opinions, LVHT patients require anticoagulation if they meet the criteria for anticoagulation or an ICD if they meet the appropriate criteria. Heart failure therapy is equal to patients with other causes of heart failure.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.