Evidence map›Paper›PMID 32648717›Full record

ArticleESC heart failure2020

Extracellular vesicle Cystatin C and CD14 are associated with both renal dysfunction and heart failure.

Laura Verbree-Willemsen, Ya-Nan Zhang, Irwani Ibrahim, Shirley B S Ooi, Jiong-Wei Wang, Muhammad I Mazlan, Win S Kuan, Siew-Pang Chan, Linda M Peelen, Diederick E Grobbee and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

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  11. New Biomarkers for Cardiovascular Disease.Texas Heart Institute journal · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 4 countries.

Laura Verbree-WillemsenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Ya-Nan ZhangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Irwani IbrahimDepartment of Emergency Medicine, National University Health System Singapore, Singapore.
Shirley B S OoiDepartment of Emergency Medicine, National University Health System Singapore, Singapore.
Jiong-Wei WangDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Muhammad I MazlanDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Win S KuanDepartment of Emergency Medicine, National University Health System Singapore, Singapore.
Siew-Pang ChanCardiovascular Research Institute, National University Heart Centre Singapore, Singapore.
Linda M PeelenJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
Diederick E GrobbeeJulius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.
A Mark RichardsCardiovascular Research Institute, National University Heart Centre Singapore, Singapore.
Carolyn S P LamNational Heart Centre Singapore, Duke-NUS Graduate Medical School, Singapore.
Dominique P V de KleijnDepartment of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
National University of Singapore · SGNational University Health System · SGUtrecht University · NLNational Heart Centre Singapore · SGUniversity of Otago · NZ

Funding

ATTRaCT SPFKNAWNational Medical Research Council Center GrantNational Medical Research Council CS-IRGNational University of SingaporeQueen of Hearts
6 · The paper itself

Abstract

aimsExtracellular vesicles (EVs) are small double-membrane plasma vesicles that play key roles in cellular crosstalk and mechanisms such as inflammation. The role of EVs in combined organ failure such as cardiorenal syndrome has not been investigated. The aim of this study is to identify EV proteins that are associated with renal dysfunction, heart failure, and their combination in dyspnoeic patients. METHODS AND

resultsBlood samples were prospectively collected in 404 patients presenting with breathlessness at the emergency department at National University Hospital, Singapore. Renal dysfunction was defined as estimated glomerular filtration rate < 60 mL/min/1.73 m

conclusionsWe provide the first data showing that Cystatin C and CD14 in circulating EVs are associated with both renal dysfunction and heart failure in patients presenting with acute dyspnoea. This suggests that EV proteins may be involved in the combined organ failure of the cardiorenal syndrome and may represent possible targets for prevention or treatment.

Indexed as

Extracellular VesiclesHeart FailureKidney DiseasesCystatin CHumansLipopolysaccharide ReceptorsSingaporeCD14 protein, humanCST3 protein, humanCystatin CLipopolysaccharide ReceptorsCardiorenal syndromeCD14Cystatin CExtracellular vesiclesHeart failureRenal insufficiency

Identifiers

PMID32648717
PMCPMC7524227
OpenAlexW3041078858

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.