Evidence map›Paper›PMID 32653544›Full record

SynthesisJACC. Cardiovascular imaging2020

Myocarditis in Relation to Angiographic Findings in Patients With Provisional Diagnoses of MINOCA.

Anaïs Hausvater, Nathaniel R Smilowitz, Boyangzi Li, Gabriel Redel-Traub, Mary Quien, Yingzhi Qian, Judy Zhong, Joseph M Nicholson, Giovanni Camastra, Loïc Bière and 7 more

Open access · greenAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in JACC. Cardiovascular imaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Review
  9. Article
  10. Review
  11. Article
  12. Role of Endomyocardial Biopsy in Diagnostics of Myocarditis.Diagnostics (Basel, Switzerland) · 2022
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

Anaïs HausvaterSoter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York.
Nathaniel R SmilowitzSoter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York.
Boyangzi LiDepartment of Medicine, New York University School of Medicine, New York, New York.
Gabriel Redel-TraubDepartment of Medicine, New York University School of Medicine, New York, New York.
Mary QuienDepartment of Medicine, New York University School of Medicine, New York, New York.
Yingzhi QianDepartment of Population Health, New York University School of Medicine, New York, New York.
Judy ZhongDepartment of Population Health, New York University School of Medicine, New York, New York.
Joseph M NicholsonHealth Sciences Library, New York University School of Medicine, New York, New York.
Giovanni CamastraCardiac Department, Vannini Hospital Rome, Rome, Italy.
Loïc BièreInstitut MITOVASC, Remodelage et Thrombose, Service de Cardiologie, CHU d'Angers, Angers, France.
Roman Panovský1st Department of Internal Medicine/Cardioangiology and International Clinical Research Center, St. Anne's Faculty Hospital, Faculty of Medicine, Masaryk University, Brno, Czech Republic.
Montenegro SáDepartment of Cardiology, Centro Hospitalar de Leiria, Leiria, Portugal.
Edouard GerbaudCardiology Intensive Care Unit and Interventional Cardiology, Hôpital Cardiologique du Haut Lévêque, Pessac, France; Bordeaux Cardio-Thoracic Research Centre, U1045, Bordeaux University, Bordeaux, France.
Joseph B SelvanayagamDepartment of Cardiovascular Medicine, Flinders University of South Australia, Adelaide, Australia.
Mouaz H Al-MallahHouston Methodist DeBakey Heart & Vascular Center, Houston Methodist Hospital, Houston, Texas.
Tilman EmrichDepartment of Diagnostic and Interventional Radiology, University Medical Center Johannes Gutenberg University Mainz, Mainz, Germany; German Center for Cardiovascular Research, partner site Rhine-Main, University Medical Center, Johannes Gutenberg University, Mainz, Germany.
Harmony R ReynoldsSoter Center for Women's Cardiovascular Research, Leon H. Charney Division of Cardiology, Department of Medicine, New York University School of Medicine, New York, New York. Electronic address: harmony.reynolds@nyulangone.org.
New York University · USFlinders University · AUHouston Methodist · USInstituto Politécnico de Leiria · PT

Funding

Project-005UL1TR001445 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI BREDELLA, MIRIAM ANTOINETTE, HOCHMAN, JUDITH S · 2015 to 2025
$103.5M
Institutional Career DevelopmentKL2TR001446 · NCATS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI PILLINGER, MICHAEL · 2015 to 2025
$6.7M
NCATS NIH HHS KL2 TR001446NCATS NIH HHS UL1 TR001445
6 · The paper itself

Abstract

objectivesThe aim of this study was to determine the prevalence of myocarditis among patients presenting with myocardial infarction with nonobstructive coronary arteries (MINOCA) in relation to the angiographic severity of nonobstructive coronary artery disease (CAD).

backgroundMINOCA represents about 6% of all cases of acute myocardial infarction. Myocarditis is a diagnosis that may be identified by cardiac magnetic resonance (CMR) imaging in patients with a provisional diagnosis of MINOCA.

methodsA systematic review was performed to identify studies reporting the results of CMR findings in MINOCA patients with nonobstructive CAD or normal coronary arteries. Study-level and individual patient data meta-analyses were performed using fixed- and random-effects methods.

resultsTwenty-seven papers were included, with 2,921 patients with MINOCA; CMR findings were reported in 2,866 (98.1%). Myocarditis prevalence was 34.5% (95% confidence interval [CI]: 27.2% to 42.2%) overall and was numerically higher in studies that defined MINOCA as myocardial infarction with angiographically normal coronary arteries compared with a definition that permitted nonobstructive CAD (45.9% vs. 32.3%; p = 0.16). In a meta-analysis of individual patient data from 9 of the 27 studies, the pooled prevalence of CMR-confirmed myocarditis was greater in patients with angiographically normal coronary arteries than in those with nonobstructive CAD (51% [95% CI: 47% to 56%] vs. 23% [95% CI: 18% to 27%]; p < 0.001). Men and younger patients with MINOCA were more likely to have myocarditis. Angiographically normal coronary arteries were associated with increased odds of myocarditis after adjustment for age and sex (adjusted odds ratio: 2.30; 95% CI: 1.12 to 4.71; p = 0.023).

conclusionsPatients with a provisional diagnosis of MINOCA are more likely to have CMR findings consistent with myocarditis if they have angiographically normal coronary arteries.

Indexed as

Coronary Artery DiseaseMyocardial InfarctionMyocarditisCoronary AngiographyCoronary VesselsFemaleHumansMalePredictive Value of TestsRisk Factorscardiac magnetic resonancemyocardial infarctionmyocarditis

Identifiers

PMID32653544
PMCPMC9132767
OpenAlexW3041786499

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.