Evidence map›Paper›PMID 32654153›Full record

ArticleMedical physics2020

CT-based multi-organ segmentation using a 3D self-attention U-net network for pancreatic radiotherapy.

Yingzi Liu, Yang Lei, Yabo Fu, Tonghe Wang, Xiangyang Tang, Xiaojun Jiang, Walter J Curran, Tian Liu, Pretesh Patel, Xiaofeng Yang

Abstract read
In one paragraph

Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Artificial Intelligence in Pancreatic Imaging: A Systematic Review.United European gastroenterology journal · 2025
    Pooled it
  2. Article
  3. A few-shot u-net learning framework for fast and accurate three-dimensional dose prediction in radiotherapy.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2025
    Article
  4. Article
  5. Sex-Based Bias in Artificial Intelligence-Based Segmentation Models in Clinical Oncology.Clinical oncology (Royal College of Radiologists (Great Britain)) · 2025
    Review
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  16. A Survey on Deep Learning for Precision Oncology.Diagnostics (Basel, Switzerland) · 2022
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingzi LiuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Yang LeiDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Yabo FuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Tonghe WangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Xiangyang TangDepartment of Radiology and Imaging Sciences and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Xiaojun JiangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Walter J CurranDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Tian LiuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Pretesh PatelDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Xiaofeng YangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.

Funding

Hybrid virtual-MRI/CBCT: A new paradigm for image guidance in liver SBRTR01EB028324 · NIBIB · UNIVERSITY OF MARYLAND BALTIMORE · PI REN, LEI, YIN, FANG-FANG · 2019 to 2022
$2.1M
Multiparametric MRI-guided Prostate HDR Brachytherapy with Focal Tumor BoostR01CA215718 · NCI · EMORY UNIVERSITY · PI YANG, XIAOFENG · 2018 to 2022
$1.8M
Emory Winship Cancer InstituteHHS | National Institutes of Health (NIH) R01CA215718NCI NIH HHS R01 CA215718NIBIB NIH HHS R01 EB028324
6 · The paper itself

Abstract

purposeSegmentation of organs-at-risk (OARs) is a weak link in radiotherapeutic treatment planning process because the manual contouring action is labor-intensive and time-consuming. This work aimed to develop a deep learning-based method for rapid and accurate pancreatic multi-organ segmentation that can expedite the treatment planning process.

methodsWe retrospectively investigated one hundred patients with computed tomography (CT) simulation scanned and contours delineated. Eight OARs including large bowel, small bowel, duodenum, left kidney, right kidney, liver, spinal cord and stomach were the target organs to be segmented. The proposed three-dimensional (3D) deep attention U-Net is featured with a deep attention strategy to effectively differentiate multiple organs. Performance of the proposed method was evaluated using six metrics, including Dice similarity coefficient (DSC), sensitivity, specificity, Hausdorff distance 95% (HD95), mean surface distance (MSD) and residual mean square distance (RMSD).

resultsThe contours generated by the proposed method closely resemble the ground-truth manual contours, as evidenced by encouraging quantitative results in terms of DSC, sensitivity, specificity, HD95, MSD and RMSD. For DSC, mean values of 0.91 ± 0.03, 0.89 ± 0.06, 0.86 ± 0.06, 0.95 ± 0.02, 0.95 ± 0.02, 0.96 ± 0.01, 0.87 ± 0.05 and 0.93 ± 0.03 were achieved for large bowel, small bowel, duodenum, left kidney, right kidney, liver, spinal cord and stomach, respectively.

conclusionsThe proposed method could significantly expedite the treatment planning process by rapidly segmenting multiple OARs. The method could potentially be used in pancreatic adaptive radiotherapy to increase dose delivery accuracy and minimize gastrointestinal toxicity.

Indexed as

Radiation OncologyDuodenumHumansPancreasRetrospective StudiesTomography, X-Ray Computedadaptive radiotherapymulti-organ segmentationpancreatic radiotherapytreatment planning

Identifiers

PMID32654153
PMCPMC8278307

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.