Evidence map›Paper›PMID 32654539›Full record

SynthesisCirculation2020

Association of Factor V Leiden With Subsequent Atherothrombotic Events: A GENIUS-CHD Study of Individual Participant Data.

Bakhtawar K Mahmoodi, Vinicius Tragante, Marcus E Kleber, Michael V Holmes, Amand F Schmidt, Raymond O McCubrey, Laurence J Howe, Kenan Direk, Hooman Allayee, Ekaterina V Baranova and 74 more

Open access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Clinical Impact of Inherited Thrombophilia in Patients With Thrombosis: Evaluating the Real Risk of FVL, PTG20210A, and MTHFR Mutations in the Kurdistan Region of Iraq.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

84 authors at 20 institutions in 16 countries.

Bakhtawar K MahmoodiSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.).
Vinicius TraganteDepartment of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.
Marcus E KleberVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.).
Michael V HolmesClinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health and Medical Research Council Population Health Research Unit, University of Oxford, United Kingdom (M.V.H.).
Amand F SchmidtDepartment of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.
Raymond O McCubreyIntermountain Heart Institute, Intermountain Medical Center, Salt Lake City, UT (R.O.McC.).
Laurence J HoweInstitute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).
Kenan DirekInstitute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).
Hooman AllayeeDepartments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of University of Southern California, Los Angeles.
Ekaterina V BaranovaDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.).
Graciela E DelgadoVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.).
Niclas ErikssonUppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).
Crystel M GijsbertsLaboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, Utrecht University, the Netherlands.
Yan GongDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville.
Jaana HartialaDepartments of Preventive Medicine and Biochemistry and Molecular Medicine (H.A., J.H.), Keck School of Medicine of University of Southern California, Los Angeles.
Mahyar HeydarpourDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (M.H., J.D.M.).
Gerard PasterkampDepartment of Clinical Chemistry (G.Pasterkamp), UMC Utrecht, Utrecht University, the Netherlands.
Salma KottiAssistance Publique-Hôpitaux de Paris (APHP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), France (S.K.).
Pekka KuukasjärviDepartments of Cardio-Thoracic Surgery (P.K., J.O.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Petra A LenziniDepartment of Genetics, Statistical Genomics Division (P.A.L., S.C.), Washington University School of Medicine, Saint Louis, MO.
Daniel LevinDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.).
Leo-Pekka LyytikäinenClinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Jochen D MuehlschlegelDepartment of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Boston, MA (M.H., J.D.M.).
Christopher P NelsonLaboratory of Experimental Cardiology (C.M.G.), UMC Utrecht, Utrecht University, the Netherlands.
Kjell NikusCardiology (K.N.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Anna P PilbrowThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
W H Wilson TangDepartment of Cardiovascular and Metabolic Sciences, Lerner Research institute (W.H.W.T., S.L.H.), Cleveland Clinic, OH.
Sander W van der LaanCentral Diagnostics Laboratory, Division Laboratories, Pharmacy, and Biomedical Genetics (S.W.v.d.L.), UMC Utrecht, Utrecht University, the Netherlands.
Jessica van SettenDepartment of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.
Ragnar O VilmundarsonRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (R.O.V., A.F.R.S.).
John DeanfieldInstitute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).
Panos DeloukasWilliam Harvey Research Institute, Barts and the London Medical School, and the Centre for Genomic Health, Queen Mary University of London, United Kingdom (P.D.).
Frank DudbridgeDepartment of Health Sciences, University of Leicester, United Kingdom (F.D.).
Stefan JamesUppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).
Ify R MordiDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.).
Andrej TerenHeart Center Leipzig, Germany (A.T.).
Thomas O BergmeijerSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.).
Simon C BodyDepartment of Anesthesiology, Boston University School of Medicine, MA (S.C.B.).
Michiel BotsJulius Center for Health Sciences and Primary Care (M.B., D.E.G.), UMC Utrecht, Utrecht University, the Netherlands.
Ralph BurkhardtLIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany.
Rhonda M Cooper-DeHoffDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville.
Sharon CresciDepartment of Genetics, Statistical Genomics Division (P.A.L., S.C.), Washington University School of Medicine, Saint Louis, MO.
Nicolas DanchinAssistance Publique-Hôpitaux de Paris (APHP), Department of Cardiology, Hôpital Européen Georges Pompidou; FACT (french Alliance for cardiovascular trials); and Université Paris Descartes, France (N.D.).
Robert N DoughtyHeart Health Research Group, University of Auckland, New Zealand (R.N.D.).
Diederick E GrobbeeJulius Center for Health Sciences and Primary Care (M.B., D.E.G.), UMC Utrecht, Utrecht University, the Netherlands.
Emil HagströmDepartment of Medical Sciences, Cardiology, Uppsala University, Sweden (S.J., E.H., C.H., A.Å., L.W.).
Stanley L HazenDepartment of Cardiovascular and Metabolic Sciences, Lerner Research institute (W.H.W.T., S.L.H.), Cleveland Clinic, OH.
Claes HeldUppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).
Imo E HoeferDepartment of Clinical Chemistry and Hematology (I.E.H.), UMC Utrecht, Utrecht University, the Netherlands.
G Kees HovinghDepartment of Vascular Medicine (G.K.H.), Academic Medical Center, University of Amsterdam, The Netherlands.
Julie A JohnsonDepartment of Pharmacotherapy and Translational Research and Center for Pharmacogenomics (Y.G., R.M.C.-D.H., J.A.J.), University of Florida, Gainesville.
Marcin P KaczorDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.).
Mika KähönenClinical Physiology (M.K.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Olaf H KlungelDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands.
Jari O LaurikkaDepartments of Cardio-Thoracic Surgery (P.K., J.O.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Terho LehtimäkiClinical Chemistry (L.-P.L., T.L.), Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Techonology, Tampere University, Finland.
Anke H Maitland-van der ZeeDivision of Pharmacoepidemiology and Clinical Pharmacology (E.V.B., O.H.K., A.H.M.-v.d.Z.), UMC Utrecht, Utrecht University, the Netherlands.
Ruth McPhersonDepartments of Medicine and Biochemistry, Microbiology, and Immunology, University of Ottawa, Ontario, Canada (R.McP. R.O.V., A.F.R.S.).
Colin N PalmerPat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, Dundee, United Kingdom (C.N.P.).
Adriaan O KraaijeveldDepartment of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.
Carl J PepineCollege of Medicine, Division of Cardiovascular Medicine (R.M.C.-D.H., J.A.J., C.J.P.), University of Florida, Gainesville.
Marek SanakDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.).
Naveed SattarInstitute of Cardiovascular and Medical Sciences, University of Glasgow, United Kingdom (N.S.).
Markus ScholzLIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany.
Tabassome SimonAssistance Publique-Hôpitaux de Paris (APHP), Department of Clinical Pharmacology, Platform of Clinical Research of East Paris (URCEST-CRCEST-CRB HUEP-UPMC), FACT (French Alliance for Cardiovascular trials); Sorbonne Université, Paris-06, France (T.S.).
John A SpertusUniversity of Missouri-Kansas City (J.A.S.).
Alexandre F R StewartRuddy Canadian Cardiovascular Genetics Centre, University of Ottawa Heart Institute, Ontario, Canada (R.O.V., A.F.R.S.).
Wojciech SzczeklikDepartment of Internal Medicine, Jagiellonian University Medical College, Kraków, Poland (M.P.K., M.Sanak, W.S.).
Joachim ThieryLIFE Research Center for Civilization Diseases (A.T., R.B., M.Scholz, J.T.), University of Leipzig, Germany.
Frank L J VisserenDepartment of Vascular Medicine (F.L.J.V.), UMC Utrecht, Utrecht University, the Netherlands.
Johannes WaltenbergerDepartment of Cardiovascular Medicine, University of Münster, Germany (J.W.).
A Mark RichardsThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
Chim C LangDivision of Molecular and Clinical Medicine, School of Medicine, University of Dundee, Scotland, United Kingdom (D.L., I.R.M., C.C.L.).
Vicky A CameronThe Christchurch Heart Institute, University of Otago Christchurch, New Zealand (A.P.P., A.M.R., V.A.C.).
Axel ÅkerblomUppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).
Guillaume PareDepartment of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada (G.Pare).
Winfried MärzVth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Germany (M.E.K., G.E.D., W.M.).
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, BHF Cardiovascular Research Centre, Glenfield Hospital, United Kingdom (P.S.B., C.P.N., N.J.S.).
Aroon D HingoraniInstitute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).
Jurriën M Ten BergSt. Antonius Hospital, Department of Cardiology, Nieuwegein, the Netherlands (B.K.M., T.O.B., J.M.t.B.).
Lars Wallentin *Uppsala Clinical Research Center, Sweden (N.E., S.J., C.H., A.Å., L.W.).
Folkert W Asselbergs *Department of Cardiology, Division Heart and Lungs (V.T., A.F.S., J.v.S., A.O.K., F.W.A.), UMC Utrecht, Utrecht University, the Netherlands.
Riyaz S Patel *Institute of Cardiovascular Science and UCL BHF Research Accelerator, Faculty of Population Health Science, University College London, United Kingdom (A.F.S., L.J.H., K.D., J.D., A.D.H., F.W.A., R.S.P.).
Utrecht University · NLTampere University of Applied Sciences · FIBritish Heart Foundation · GBUppsala University · SEJagiellonian University · PLPharmacoGenetics (China) · CNUniversity of Dundee · GBAnna Needs Neuroblastoma Answers · USBrigham and Women's Hospital · USCleveland Clinic · USGlenfield Hospital · GBHeidelberg University · DELife University · USNetherlands Heart Institute · NLSorbonne Université · FRSt. Antonius Ziekenhuis · NLUniversity Medical Center Utrecht · NLUniversity of Otago · NZUniversity of Ottawa · CAUniversity of Southern California · US

Funding

Structural Determinants Of Ceruloplasmin Inflammatory ActivityP01HL076491 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI PLOW, EDWARD FRANKLIN · 2004 to 2019
$27.3M
Pharmacogenomic Evaluation of Antihypertensive ResponsesU01GM074492 · NIGMS · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2005 to 2014
$20.7M
SCCOR in Cardiac Dysfunction and DiseaseP50HL077113 · NHLBI · WASHINGTON UNIVERSITY · PI KELLY, DANIEL PATRICK · 2005 to 2009
$13.4M
Regression of Atherosclerosis CoreP01HL098055 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2014
$12.1M
Gut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8M
Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
Genomic variants associated with angina and health status outcome after MIR01NR013396 · NINR · WASHINGTON UNIVERSITY · PI CRESCI, SHARON · 2011 to 2019
$4.5M
INTEGRATIVE GENETIC APPROACHES TO GENE-AIR POLLUTION INTERACTIONS IN ASTHMAR01ES021801 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI AKBARI, OMID, ALLAYEE, HOOMAN · 2012 to 2016
$3.9M
Nitrative stress in heart failureR01HL103931 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI TANG, WAI HONG WILSON · 2010 to 2014
$3.8M
Hypertension PharmacogeneticsR01HL074730 · NHLBI · UNIVERSITY OF FLORIDA · PI JOHNSON, JULIE A. · 2003 to 2006
$3.4M
Nutrigenetic Intervention to Reduce Liver Fat in Hispanics - SupplementR01MD010358 · NIMHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN, GORAN, MICHAEL ISAAC · 2016 to 2019
$3.3M
Role of Glycine Metabolism in Cardiovascular DiseaseR01HL133169 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ALLAYEE, HOOMAN · 2017 to 2020
$3.3M
British Heart Foundation FS/18/23/33512British Heart Foundation PG/18/50/33837British Heart Foundation RG/10/12/28456British Heart Foundation SP/13/6/30554Medical Research Council G0600580Medical Research Council G0601354Medical Research Council G0801414Medical Research Council G0801566Medical Research Council G0802318Medical Research Council G0902037Medical Research Council MR/K006584/1Medical Research Council MR/K013351/1NHLBI NIH HHS P01 HL076491NHLBI NIH HHS P01 HL098055NHLBI NIH HHS P20 HL113452NHLBI NIH HHS P50 HL077113NHLBI NIH HHS R01 HL074730NHLBI NIH HHS R01 HL098601NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL103931NHLBI NIH HHS R01 HL126827NHLBI NIH HHS R01 HL133169NHLBI NIH HHS R01 HL148110NIDDK NIH HHS R01 DK106000NIEHS NIH HHS R01 ES021801NIEHS NIH HHS R01 ES025786NIGMS NIH HHS U01 GM074492NIMHD NIH HHS R01 MD010358NINR NIH HHS R01 NR013396Wellcome TrustWellcome Trust 072960/Z/03/ZWellcome Trust 084726/Z/08/ZWellcome Trust 084727/Z/08/ZWellcome Trust 085475/B/08/ZWellcome Trust 085475/Z/08/Z
6 · The paper itself

Abstract

backgroundStudies examining the role of factor V Leiden among patients at higher risk of atherothrombotic events, such as those with established coronary heart disease (CHD), are lacking. Given that coagulation is involved in the thrombus formation stage on atherosclerotic plaque rupture, we hypothesized that factor V Leiden may be a stronger risk factor for atherothrombotic events in patients with established CHD.

methodsWe performed an individual-level meta-analysis including 25 prospective studies (18 cohorts, 3 case-cohorts, 4 randomized trials) from the GENIUS-CHD (Genetics of Subsequent Coronary Heart Disease) consortium involving patients with established CHD at baseline. Participating studies genotyped factor V Leiden status and shared risk estimates for the outcomes of interest using a centrally developed statistical code with harmonized definitions across studies. Cox proportional hazards regression models were used to obtain age- and sex-adjusted estimates. The obtained estimates were pooled using fixed-effect meta-analysis. The primary outcome was composite of myocardial infarction and CHD death. Secondary outcomes included any stroke, ischemic stroke, coronary revascularization, cardiovascular mortality, and all-cause mortality.

resultsThe studies included 69 681 individuals of whom 3190 (4.6%) were either heterozygous or homozygous (n=47) carriers of factor V Leiden. Median follow-up per study ranged from 1.0 to 10.6 years. A total of 20 studies with 61 147 participants and 6849 events contributed to analyses of the primary outcome. Factor V Leiden was not associated with the combined outcome of myocardial infarction and CHD death (hazard ratio, 1.03 [95% CI, 0.92-1.16];

conclusionsFactor V Leiden was not associated with increased risk of subsequent atherothrombotic events and mortality in high-risk participants with established and treated CHD. Routine assessment of factor V Leiden status is unlikely to improve atherothrombotic events risk stratification in this population.

Indexed as

GenotypeAtherosclerosisClinical Trials as TopicCoronary DiseaseFactor VGenetic Predisposition to DiseaseHumansPolymorphism, Single NucleotidePrecision MedicinePrognosisRiskThrombosisFactor Vfactor V Leidencoronary artery diseasegenetic association studiesmyocardial infarctionprognosissecondary preventionsingle nucleotide polymorphismthrombosis

Identifiers

PMID32654539
PMCPMC7493828
OpenAlexW3041166249

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.