ArticleAmerican journal of translational research2020
BMP4-mediated autophagy is involved in the metastasis of hepatocellular carcinoma
Article in American journal of translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 13 citations in OpenAlex.
- BMP4 upregulates glycogen synthesis through the SMAD/SLC2A1 (GLUT1) signaling axis in hepatocellular carcinoma (HCC) cells.Cancer & metabolism · 2023Article
- Role and Mechanism of BMP4 in Regenerative Medicine and Tissue Engineering.Annals of biomedical engineering · 2023Review
- BMP-induced non-canonical signaling is upregulated during autophagy-mediated regeneration in inflamed mesothelial cells.Scientific reports · 2023Article
- Targeting and regulation of autophagy in hepatocellular carcinoma: revisiting the molecular interactions and mechanisms for new therapy approaches.Cell communication and signaling : CCS · 2023Review
- Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts.The European respiratory journal · 2022Article
- FGF10 ameliorates lipopolysaccharide-induced acute lung injury in miceFrontiers in pharmacology · 2022Article
- BMP4 augments the survival of hepatocellular carcinoma (HCC) cells under hypoxia and hypoglycemia conditions by promoting the glycolysis pathway.American journal of cancer research · 2021Article
- Autophagy Process in Trophoblast Cells Invasion and Differentiation: Similitude and Differences With Cancer Cells.Frontiers in oncology · 2021Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of autophagy in tumor development is complicated. More signaling mechanisms of bone morphogenetic protein 4 (BMP4) involving in hepatocellular carcinoma (HCC) are needed to be clarified. The present study aimed to identify whether BMP4 contributes to the regulation of autophagy in the progression of HCC. We found that increased BMP4 expression was significantly correlated with TNM stage and metastasis. BMP4 treatment promoted HCC cells invasion and induced autophagy. Blocking autophagy by 3-MA or silenced Beclin1 attenuated BMP4-induced autophagy and cell invasion. Further study revealed that JNK/Beclin1 pathway participated in the process of autophagy and JNK inhibitor SP600125 could attenuate autophagy and reduce the invasive ability of HCC cells induced by BMP4. In a word, BMP4-induced autophagy facilitates invasion of HCC by JNK/Beclin1 signaling pathway.
Indexed as
Identifiers
32655831PMC7344099W3043733526What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.