Evidence map›Paper›PMID 32656486›Full record

ArticleEnvironmental epidemiology (Philadelphia, Pa.)2020

A prospective cohort study of in utero and early childhood arsenic exposure and infectious disease in 4- to 5-year-old Bangladeshi children.

Sharia M Ahmed, Adam Branscum, Barrett M Welch, Meghan Megowan, Jeffrey W Bethel, Michelle C Odden, Sakila Afroz Joya, M Omar Sharif Ibn Hasan, Pi-I Lin, Golam Mostofa and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environmental epidemiology (Philadelphia, Pa.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 2 countries.

Sharia M AhmedOregon State University, Corvallis, Oregon, USA.
Adam BranscumOregon State University, Corvallis, Oregon, USA.
Barrett M WelchOregon State University, Corvallis, Oregon, USA.
Meghan MegowanOregon State University, Corvallis, Oregon, USA.
Jeffrey W BethelOregon State University, Corvallis, Oregon, USA.
Michelle C OddenStanford University, Stanford, California, USA.
Sakila Afroz JoyaDhaka Community Hospital Trust, Dhaka, Bangladesh.
M Omar Sharif Ibn HasanDhaka Community Hospital Trust, Dhaka, Bangladesh.
Pi-I LinHarvard T.H. Chan School of Public Health, Harvard, Boston, Massachusetts, USA.
Golam MostofaDhaka Community Hospital Trust, Dhaka, Bangladesh.
Quazi QuamruzzamanDhaka Community Hospital Trust, Dhaka, Bangladesh.
Mahmudur RahmanDhaka Community Hospital Trust, Dhaka, Bangladesh.
David C ChristianiHarvard T.H. Chan School of Public Health, Harvard, Boston, Massachusetts, USA.
Molly L KileOregon State University, Corvallis, Oregon, USA.
Dhaka Community Hospital Trust · BDOregon State University · USStanford University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious research found that infants who were exposed to high levels of arsenic in utero had an increased risk of infectious disease in the first year of life. This prospective study examined the association between arsenic exposures during gestation, and respiratory, diarrheal, and febrile morbidity in children 4-5 years of age.

methodsA cohort of pregnant women was recruited in 2008-2011 in Bangladesh. Their children (N = 989) were followed, and household drinking water samples were collected during pregnancy, toddlerhood (12-40 months of age), and childhood (4-5 years of age). We actively surveyed mothers every 2 weeks regarding their children's infectious diseases symptoms from 4 to 5 years of age. Poisson regression models were used to estimate the association between arsenic exposure and respiratory and febrile illness.

resultsMedian drinking water arsenic was 4.6, 8.8, and 4.2 µg/L in pregnancy, toddlerhood, and childhood, respectively. We observed 0.01, 1.2, and 1.0 cases per 100 person-days of diarrhea, respiratory, and febrile illness, respectively. The incident rate ratios (IRRs) for each doubling of drinking water arsenic during pregnancy were 1.10 (95% confidence interval [CI] = 1.00, 1.22) and 0.93 (95% CI = 0.82, 1.05) for respiratory and febrile illness, respectively, after adjusting for covariates. The association between arsenic exposure measured during toddlerhood and childhood was attenuated and not significantly associated with either outcome. Diarrheal disease was too infrequent to assess.

conclusionsDrinking water arsenic exposure during pregnancy was associated with a higher risk of acute respiratory infections in children 4-5 years old in Bangladesh.

Indexed as

ArsenicBangladeshDevelopmental immunotoxicityPregnancyRespiratory infectionWindows of susceptibility

Identifiers

PMID32656486
PMCPMC7319226
OpenAlexW3005561414

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.