Evidence map›Paper›PMID 32656545›Full record

ArticleeMedical research2020

Oxidized Glutathione Increases Delta-Subunit Expressing Epithelial Sodium Channel Activity in

Garett J Grant, Camila Coca, Xing-Ming Zhao, My N Helms

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in eMedical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Epithelial NaComprehensive Physiology · 2024
    Review
  2. Enhanced epithelial sodium channel activity in neonatal Scnn1b mouse lung attenuates high oxygen-induced lung injury.American journal of physiology. Lung cellular and molecular physiology · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Garett J GrantDepartment of Internal Medicine, Pulmonary Division, University of Utah, Salt Lake City, UT, USA.
Camila CocaDepartment of Internal Medicine, Pulmonary Division, University of Utah, Salt Lake City, UT, USA.
Xing-Ming ZhaoInstitute of Science and Technology for Brain Inspired Intelligence, Fudan University, Shanghai, China.
My N HelmsDepartment of Internal Medicine, Pulmonary Division, University of Utah, Salt Lake City, UT, USA.
Fudan University · CN

Funding

Oxidized glutathione regulation of epithelial sodium channels in newborn lung injuryR01HL137033 · NHLBI · UNIVERSITY OF UTAH · PI HELMS, MY N. · 2018 to 2021
$1.5M
NHLBI NIH HHS R01 HL137033
6 · The paper itself

Abstract

Epithelial sodium channels (ENaC) are heterotrimeric structures, made up of α, β, and γ subunits, and play an important role in maintaining fluid homeostasis. When δ-ENaC subunits are expressed in place of (or in addition to) the α-ENaC subunit alongside β- and γ- subunits, fundamental changes in the biophysical properties of ENaC can be observed. Using human ENaC cRNA constructs and the

Indexed as

Cys thiolsglutathione disulfideoocytesS-glutathionylationTwo Electrode Voltage Clamp (TEV)

Identifiers

PMID32656545
PMCPMC7351335
OpenAlexW3042226646

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.