ArticleThe EMBO journal2020
Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism.
Article in The EMBO journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Adhesion to a common ECM mediates interdependence in tissue morphogenesis in Drosophila.EMBO reports · 2026Article
- Plasma membrane invaginations and their diverse cellular functions.BMC biology · 2026Review
- Intestinal epithelial PTPN23 is essential for gut barrier integrity and prevention of fatal bacterial translocation.Journal of Crohn's & colitis · 2025Article
- The TNFR Wengen regulates the FGF pathway by an unconventional mechanism.Nature communications · 2023Article
- Lateral adherens junctions mediate a supracellular actomyosin cortex in drosophila trachea.iScience · 2023Article
- NDR kinase tricornered genetically interacts with Ccm3 and metabolic enzymes in Drosophila melanogaster tracheal development.G3 (Bethesda, Md.) · 2023Article
- Identification and validation of candidate risk genes in endocytic vesicular trafficking associated with esophageal atresia and tracheoesophageal fistulas.HGG advances · 2022Article
- An endosome-associated actin network involved in directed apical plasma membrane growth.The Journal of cell biology · 2022Article
- Review
- Crosstalk between basal extracellular matrix adhesion and building of apical architecture during morphogenesis.Biology open · 2021Review
- High-precision targeting workflow for volume electron microscopy.The Journal of cell biology · 2021Article
- Transcytosis in the development and morphogenesis of epithelial tissues.The EMBO journal · 2021Review
- Article
- Rab GTPases in Osteoclastic Bone Resorption and Autophagy.International journal of molecular sciences · 2020Review
- Transcytosis via the late endocytic pathway as a cell morphogenetic mechanism.The EMBO journal · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Plasma membranes fulfil many physiological functions. In polarized cells, different membrane compartments take on specialized roles, each being allocated correct amounts of membrane. The Drosophila tracheal system, an established tubulogenesis model, contains branched terminal cells with subcellular tubes formed by apical plasma membrane invagination. We show that apical endocytosis and late endosome-mediated trafficking are required for membrane allocation to the apical and basal membrane domains. Basal plasma membrane growth stops if endocytosis is blocked, whereas the apical membrane grows excessively. Plasma membrane is initially delivered apically and then continuously endocytosed, together with apical and basal cargo. We describe an organelle carrying markers of late endosomes and multivesicular bodies (MVBs) that is abolished by inhibiting endocytosis and which we suggest acts as transit station for membrane destined to be redistributed both apically and basally. This is based on the observation that disrupting MVB formation prevents growth of both compartments.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.