Evidence map›Paper›PMID 32660025›Full record

Trial reportNutrients2020

Targeting the Intestinal Microbiota to Prevent Type 2 Diabetes and Enhance the Effect of Metformin on Glycaemia: A Randomised Controlled Pilot Study.

Talia Palacios, Luis Vitetta, Samantha Coulson, Claire D Madigan, Yan Y Lam, Rachel Manuel, David Briskey, Chelsea Hendy, Ji-Nu Kim, Thomas Ishoey and 4 more

Open access · goldFull text readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 11 pooled it
6.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 11 syntheses or guidelines pooled it, 134 citations in OpenAlex.

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  12. Review
  13. Probiotics,Metabolism open · 2025
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Talia PalaciosThe Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Luis VitettaFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-7490-9298
Samantha CoulsonFaculty of Medicine and Health, University of Sydney, Sydney, NSW 2006, Australia.
Claire D MadiganThe Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Yan Y LamDepartment of Biochemistry and Microbiology and New Jersey Institute for Food, Nutrition, and Health, School of Environmental and Biological Sciences, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0002-5724-1142
Rachel ManuelSchool of Medical Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
David BriskeySchool of Human Movement and Nutrition Sciences, Faculty of Health and Behavioural Sciences, University of Queensland, Brisbane, QLD 4072, Australia.
Chelsea HendyThe Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.
Ji-Nu KimSolarea Bio Inc., Cambridge, MA 02142, USA.
Thomas IshoeySolarea Bio Inc., Cambridge, MA 02142, USA.
Maria J Soto-GironSolarea Bio Inc., Cambridge, MA 02142, USA.ORCID 0000-0002-8033-8962
Eric M SchottSolarea Bio Inc., Cambridge, MA 02142, USA.
Gerardo ToledoSolarea Bio Inc., Cambridge, MA 02142, USA.ORCID 0000-0002-8033-2149
Ian D CatersonThe Boden Collaboration for Obesity, Nutrition, Exercise and Eating Disorders, Charles Perkins Centre, University of Sydney, Sydney, NSW 2006, Australia.ORCID 0000-0002-6139-3632
The University of Sydney · AUSolarea Bio (United States) · USRutgers, The State University of New Jersey · USThe University of Queensland · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Early treatment may prevent or delay the onset of type 2 diabetes mellitus (T2DM) in individuals who are at high risk. Lifestyle interventions and the hypoglycemic drug metformin have been shown to reduce T2DM incidence. The effectiveness of such interventions may be enhanced by targeting environmental factors such as the intestinal microbiota, which has been proven to predict the response to lifestyle interventions and play a part in mediating the glucose-lowering effects of metformin. Shifts in the intestinal microbiota "towards a more balanced state" may promote glucose homeostasis by regulating short-chain fatty acids' production. This study aimed to investigate the safety and effect of a multi-strain probiotic on glycemic, inflammatory, and permeability markers in adults with prediabetes and early T2DM and to assess whether the probiotic can enhance metformin's effect on glycaemia. A randomised controlled pilot study was conducted in 60 adults with a BMI ≥ 25 kg/m

Indexed as

Gastrointestinal MicrobiomeAgedBacillotaBacteroidetesBlood GlucoseButyratesDiabetes Mellitus, Type 2Fatty Acids, VolatileFemaleHaptoglobinsHumansHypoglycemic AgentsInsulin ResistanceMaleMetabolic Networks and PathwaysMetforminBlood GlucoseButyratesFatty Acids, VolatileHaptoglobinsHypoglycemic AgentsMetforminProtein Precursorszonulinintestinal microbiotametforminprediabetesprobioticsshort-chain fatty acidstype 2 diabetes mellitus

Identifiers

PMID32660025
PMCPMC7400852
OpenAlexW3040948317

What Socratic holds

Textfull text, public
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.