Evidence map›Paper›PMID 32661631›Full record

ArticleInternational urology and nephrology2020

Impact of chronic kidney disease on long-term outcome of patients with valvular heart defects.

Łukasz Kuźma, Jolanta Małyszko, Hanna Bachórzewska-Gajewska, Marta Maria Niwińska, Anna Kurasz, Małgorzata Zalewska-Adamiec, Marcin Kożuch, Sławomir Dobrzycki

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International urology and nephrology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04527367 (Epidemiology and Long-term Prognosis of Patients With Valvular Heart Diseases), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04527367 completednot on this map

Epidemiology and Long-term Prognosis of Patients With Valvular Heart Diseases (BIA-WAD Study)

TypeobservationalSponsorMedical University of BialystokRan2006 to 2022Enrolled2,500ConditionsValvular Disease, Valvular Heart Disease, Aortic Valve Stenosis, Mitral Insufficiency and Aortic StenosisArmsInnovative medical technologies in invasive cardiology and cardiac surgery
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. The influence of renal disease on outcomes and cardiac remodeling following surgical mitral valve replacement.Clinical research in cardiology : official journal of the German Cardiac Society · 2023
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Łukasz KuźmaDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Jolanta MałyszkoDepartment of Nephrology, Dialysis and Internal Medicine, Medical University of Warsaw, ul. Banacha 1a, 02-097, Warsaw, Poland. jolmal@poczta.onet.pl.ORCID http://orcid.org/0000-0001-8701-8171
Hanna Bachórzewska-GajewskaDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Marta Maria NiwińskaDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Anna KuraszDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Małgorzata Zalewska-AdamiecDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Marcin KożuchDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Sławomir DobrzyckiDepartment of Invasive Cardiology, Medical University of Bialystok, Bialystok, Poland.
Medical University of Białystok · PLMedical University of Warsaw · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionValvular heart diseases (VHD) are becoming a significant problem in the Polish population. Coexistence of chronic kidney disease (CKD) in patients with VHD increases the risk of death and affects further therapeutic strategy.

aimAnalysis impact of CKD on long-term prognosis in patients with VHD. MATERIAL AND

methodsThe inclusion criteria were met by 1025 patients with moderate and severe VHD. Mean observation time was 2528 ± 1454 days.

resultsThe average age of the studied population was 66.75 (SD = 10.34), male gender was dominant 56% (N = 579). Severe aortic valve stenosis (AVS) occurred in 28.2%, severe mitral valve insufficiency (MVI) in 20%. CKD occurred in 37.1% (N = 380) patients mostly with mitral stenosis (50%, N = 16) and those with severe MVI (44.8%, N = 94). During the observational period, 52.7% (N = 540) deaths were noted. Increased risk of mortality was associated mostly with age (OR: 1.02, 95% CI: 1.00-1.03, p < 0.001), creatinine (OR:1.27, 95% CI: 1.12-1.43, p < 0.001), CKD (OR: 1.30, 95% CI: 1.17-1.44, p < 0.001), reduced ejection fraction (EF) (OR: 0.98, 95% CI: 0.97-0.99, p = 0.01) and coexisting of AVS (OR: 1.19, 95% CI: 1.04-1.35, p = 0.01).

conclusionsMitral valve defects more often than aortic valve defects coexist with chronic kidney disease. Regardless of the stage, chronic kidney disease is an additional factor affecting the prognosis in patients with heart defects. Factors increasing the risk of death were age, creatinine concentration and reduced EF. The monitoring of renal function in patients with VHD should be crucial as well as the implementation of treatment at an early stage.

Indexed as

AgedFemaleHeart Valve DiseasesHumansMaleMiddle AgedPrognosisRenal Insufficiency, ChronicSeverity of Illness IndexTime FactorsAortic stenosisChronic kidney diseaseGlomerular filtration rateMitral insufficiencyValvular heart disease

Identifiers

PMID32661631
PMCPMC7575476
OpenAlexW3043818762

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.