SynthesisBioscience reports2020
Lack of association between IGF2BP2 rs4402960 polymorphism and gestational diabetes mellitus: a case-control study, meta-analysis and trial sequential analysis.
Synthesis in Bioscience reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between pregnancy-related complications and development of type 2 diabetes and hypertension in women: an umbrella review.BMC medicine · 2024Pooled it
- Association of Genetic Polymorphisms with Gestational Diabetes in a Kazakh Population: A Case-Control Study.Diagnostics (Basel, Switzerland) · 2026Article
- Assessing individual genetic susceptibility to metabolic syndrome: interpretable machine learning method.Annals of medicine · 2025Article
- Association between genetic polymorphisms and gestational diabetes mellitus susceptibility in a Chinese population.Frontiers in endocrinology · 2024Article
- The associations of IGF2, IGF2R and IGF2BP2 gene polymorphisms with gestational diabetes mellitus: A case-control study.PloS one · 2024Article
- Gestational Diabetes Mellitus (GDM) Risk for Declared Family History of Diabetes, in Combination with BMI Categories.International journal of environmental research and public health · 2021Article
- The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers.Cancer cell international · 2021Review
- Association of Common Genetic Risk Variants With Gestational Diabetes Mellitus and Their Role in GDM Prediction.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIt is well known that insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) rs4402960 polymorphism is associated with Type 2 diabetes mellitus, which has a shared genetic background with gestational diabetes mellitus (GDM). Previous studies have yielded controversial results about the link between IGF2BP2 rs4402960 polymorphism and GDM risk. Thus, a meta-analysis was performed to obtain more conclusive results.
methodsClinical and genotype data were determined for 305 GDM and 1216 healthy participants recruited. Eligible studies were retrieved in PubMed, Web of science, EMBASE, and Scopus. Odds ratios (ORs) with 95% confidence intervals (CIs) were utilized to evaluate the relationship between IGF2BP2 polymorphisms and GDM susceptibility in five genetic models. The subgroup stratified analysis and trial sequential analysis (TSA) were performed.
resultsIn this case-control study, no significant association was revealed between IGF2BP2 polymorphism and GDM (P>0.05). When combined with the previous studies in the meta-analysis, there was no statistical association between IGF2BP2 polymorphism and GDM (allele model: OR = 1.01, 95% CI = 0.86-1.18; dominant model: OR = 1.00, 95% CI = 0.81-1.24; recessive model: OR = 1.08, 95% CI = 0.91-1.29; heterozygous model: OR = 0.99, 95% CI = 0.80-1.24; homozygous model: OR = 1.06, 95% CI = 0.78-1.42). No association was observed in five genetic models in each subgroup. TSA indicated sufficient proof of such null association in the overall population.
conclusionsThis meta-analysis provides sufficient statistical evidence indicating null association between IGF2BP2 rs4402960 polymorphism and GDM risk.
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