Evidence map›Paper›PMID 32664806›Full record

ArticleExperimental biology and medicine (Maywood, N.J.)2020

JANEX-1 improves acute pulmonary embolism through VEGF and FAK in pulmonary artery smooth muscle cells.

Longfei Pan, Zhuo Peng, Ruipeng Zhang, Rui Zhang, Dean Liang, Heming Chen, Hongyan Tian

Erratum issuedOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental biology and medicine (Maywood, N.J.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Longfei PanDepartment of Peripheral Vascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
Zhuo PengDepartment of Emergency Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Ruipeng ZhangDepartment of Vascular Surgery, Shaanxi Provincial People's Hospital, Xi'an710068, China.
Rui ZhangDepartment of Emergency Medicine, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China.
Dean LiangDepartment of Vascular Surgery, Luoyang Central Hospital, Luoyang 471000, China.
Heming ChenDepartment of Peripheral Vascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.ORCID 0000-0003-0609-0142
Hongyan TianDepartment of Peripheral Vascular Medicine, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China.
First Affiliated Hospital of Xi'an Jiaotong University · CNShanxi Medical University · CNAnkang City Central Hospital · CNLuoyang Central Hospital Affiliated to Zhengzhou University · CNSecond Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

impact statementAccumulating evidence suggests that vascular remodeling due to immoderate proliferation and migration of SMCs is a common process occurring in APE. In this work, we tried to find a breakthrough in the pathological mechanism to alleviate the prognosis of APE by improving SMCs proliferation and explored the effect of JANEX-1 on PDGF-induced proliferation-related molecules in PVSMCs and assessed the therapeutic potential of JAK3 for vascular remodeling in APE mice. We demonstrated that JANEX-1, blocking JAK3 expression or activity, reduced JAK3/STAT3 signaling pathway, VEGF expression and FAK activation, and PDGF-induced proliferation of PVSMCs. Moreover, JANEX-1 inhibited the thrombus-induced intimal hyperplasia and the expression of VEGF and FAK activation in neointimal SMCs of APE mice. The data are helpful to elucidate the pharmacological mechanism and potential therapeutic effect of JANEX-1 in APE.

Indexed as

Acute DiseaseAnimalsCell ProliferationDisease Models, AnimalFocal Adhesion Protein-Tyrosine KinasesJanus Kinase 3LungMaleMice, Inbred C57BLMyocytes, Smooth MusclePhosphorylationPlatelet-Derived Growth FactorPulmonary ArteryPulmonary EmbolismQuinazolinesSTAT3 Transcription FactorFocal Adhesion Protein-Tyrosine KinasesJanus Kinase 3Platelet-Derived Growth FactorQuinazolinesSTAT3 Transcription FactorVascular Endothelial Growth Factor AWHI P131Acute pulmonary embolismFAKJAK3/STAT3 signalingJANEX-1pulmonary artery smooth muscle cellsVEGF

Identifiers

PMID32664806
PMCPMC7441354
OpenAlexW3043738773

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.