ArticleCardiovascular diabetology2020
A high triglyceride glucose index is more closely associated with hypertension than lipid or glycemic parameters in elderly individuals: a cross-sectional survey from the Reaction Study.
Article in Cardiovascular diabetology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05702112 (Association of Triglyceride-glucose Index With Cardiac Hemodynamics and Cardiovascular Risk Assesment in Obese Patient.), which is not on this map. Cited by 76 papers, 4 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Triglyceride-glucose Index With Cardiac Hemodynamics and Cardiovascular Risk Assesment in Obese Patient.
Who cites it
76 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- The triglyceride-glucose index is associated with a higher risk of hypertension: evidence from a cross-sectional study of Chinese adults and meta-analysis of epidemiology studies.Frontiers in endocrinology · 2025Pooled it
- Association between triglyceride-glucose index and hypertension: A systematic review and meta-analysis.Narra J · 2024Pooled it
- Relationship between the triglyceride-glucose index and risk of cardiovascular diseases and mortality in the general population: a systematic review and meta-analysis.Cardiovascular diabetology · 2022Pooled it
- Association Between Triglyceride-Glucose Index and Hypertension: A Meta-Analysis.Frontiers in cardiovascular medicine · 2021Pooled it
- Association of C-Reactive Protein-Triglyceride Glucose Index and TyG Index With Prehypertension and Hypertension.Immunity, inflammation and disease · 2026Article
- Triglyceride-glucose index and abnormal blood pressure in adults aged over 70 years: real-world data evidence.BMC cardiovascular disorders · 2026Article
- Body Roundness Index Mediates the Association Between Triglyceride-Glucose Index and Hypertension: A Cross-Sectional Study.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2026Article
- Association of cholesterol, high-density lipoprotein, and glucose (CHG) index with chronic kidney disease in Chinese community adults: findings from the REACTION study.Frontiers in nutrition · 2026Article
- Association of novel triglyceride-glucose index-derived indices with hyperuricemia among oilfield workers.Frontiers in nutrition · 2026Article
- Cumulative triglyceride-glucose index and hypertension risk: a longitudinal cohort study.BMC public health · 2025Observational
- Impact of Blood Pressure Across the Life Course on Arterial Stiffness in Midlife: The Mediating Role of Metabolic Factors.MedComm · 2025Article
- Associations of insulin resistance surrogate with resistant hypertension and the severity of hypertension in the chronic kidney disease population.Journal of hypertension · 2025Article
- Association Between Cognitive Dysfunction, TYG Index, and Depression in Older Adults: Based on the NHANES Database, 2011-2014.Brain and behavior · 2025Article
- Derivatives of the triglyceride-glucose index and their association with incident hypertension in prehypertensive individuals: a 4-year cohort study augmented by mendelian randomization.Cardiovascular diabetology · 2025Article
- Combined association of triglyceride-glucose index and systemic inflammation index on all-cause and cardiovascular mortality.Scientific reports · 2025Article
- The triglyceride-glucose index positively associates with the prevalence and severity of coronary heart disease in patients among hypertension.Scientific reports · 2025Article
- Triglyceride glucose-waist circumference as a predictor of mortality and subtypes of cardiovascular disease: a systematic review and meta-analysis.Diabetology & metabolic syndrome · 2025Review
- Association between triglyceride-glucose index andFrontiers in endocrinology · 2025Article
- Association between triglyceride-glucose index and obstructive sleep apnea severity in hypertensive patients with co-existing OSA: a cross-sectional study.Frontiers in endocrinology · 2025Article
- Association of Triglyceride-Glucose Index, Triglyceride to High-Density Lipoprotein Cholesterol Ratio, and Related Parameters With Prehypertension and Hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
16 more citing papers are in PubMed but not listed here.
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14 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundBoth lipid and glucose abnormalities are associated with hypertension (HTN). However, it is unclear whether the triglyceride-glucose (TyG) index is associated with HTN. Therefore the aim of this study is to investigate the association of the TyG index and HTN and to compare the discriminative power of the TyG index, lipid, glycemic parameters for the risk of HTN in elderly individuals.
methodsThe present study was nested in a longitudinal (REACTION) study from May 2011 to December 2011, which was designed to demonstrate the association of abnormal glucose metabolism with the risk of cancer in the Chinese population. In total, 47,808 participants were recruited in this cross-sectional study. The TyG index was divided into five groups: the < 20% group, the 20-39% group, the 40-59% group, the 60-79% group and the ≥ 80% group, according to quintile division of the subjects. Three multivariate logistic regression models were used to evaluate the association between the TyG vs. lipid parameters, glycemic parameters and HTN.
resultsMultivariate logistic regression analysis shows that compared with lipid and glycemic parameters, the TyG index remains significantly associated with HTN in either total subjects or subjects separated into men and women (odds ratio (OR) 1.33, 95% confidence interval (CI) 1.18-1.51, p < 0.0001 in total subjects; OR 1.39, 95% CI 1.11-1.74, p = 0.0042 in men; OR 1.28, 95% CI 1.11-1.49, p = 0.0010 in women). In a stratified analysis, an elevated TyG index is significantly associated with HTN in the subgroup of the oldest age (≥ 65) (OR 1.67, 95% CI 1.30-2.14, p < 0.0001), as well as with obesity (Body mass index (BMI) ≥ 28 kg/m
conclusionThe TyG index is significantly associated with HTN and shows the superior discriminative ability for HTN compared with lipid and glycemic parameters in the Chinese elderly population.
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