Evidence map›Paper›PMID 32665022›Full record

ArticleActa neuropathologica communications2020

Molecular and clinicopathologic features of gliomas harboring NTRK fusions.

Matthew Torre, Varshini Vasudevaraja, Jonathan Serrano, Michael DeLorenzo, Seth Malinowski, Anne-Florence Blandin, Melanie Pages, Azra H Ligon, Fei Dong, David M Meredith and 9 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta neuropathologica communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 1 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Advances in the management of pediatric low-grade glioma.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  4. Review
  5. Recent Advances in Targeted Therapies for Adult Gliomas.Current neurology and neuroscience reports · 2026
    Review
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 2 countries.

Matthew TorreDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Varshini VasudevarajaDepartment of Pathology, NYU Langone Health, 550 First Avenue, New York, NY, 10016, USA.
Jonathan SerranoDepartment of Pathology, NYU Langone Health, 550 First Avenue, New York, NY, 10016, USA.
Michael DeLorenzoDepartment of Pathology, NYU Langone Health, 550 First Avenue, New York, NY, 10016, USA.
Seth MalinowskiDepartment of Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02115, USA.
Anne-Florence BlandinDepartment of Oncologic Pathology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA, 02115, USA.
Melanie PagesDepartment of Neuropathology, GHU Paris Sainte-Anne Hospital, 1 Rue Cabanis, 75014, Paris, France.
Azra H LigonDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Fei DongDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
David M MeredithDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
MacLean P NasrallahDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street 34th St, Philadelphia, PA, 19104, USA.
Craig HorbinskiDepartment of Neurological Surgery, Northwestern University, Chicago, IL, USA.
Sonika DahiyaDivision of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8118, St. Louis, MO, 63110, USA.
Keith L LigonDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.
Mariarita SantiDepartment of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, 3400 Spruce Street 34th St, Philadelphia, PA, 19104, USA.
Shakti H RamkissoonFoundation Medicine, 7010 Kit Creek Road, Morrisville, NC, 27560, USA.
Mariella G FilbinDepartment of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, MA, 02215, USA.
Matija SnuderlDepartment of Pathology, NYU Langone Health, 550 First Avenue, New York, NY, 10016, USA.
Sanda AlexandrescuDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA. Sanda.Alexandrescu@childrens.harvard.edu.ORCID 0000-0001-9246-4184
Brigham and Women's Hospital · USNYU Langone Health · USDana-Farber Cancer Institute · USCentre Hospitalier Sainte-Anne · FRChildren's Hospital of Philadelphia · USFoundation Medicine (United States)Harvard University · USNorthwestern University · USUniversity of Pennsylvania · USWashington University in St. Louis · US

Funding

Northwestern University Clinical and Translational Science Institute (NUCATS)UL1TR001422 · NCATS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI D'AQUILA, RICHARD · 2015 to 2023
$56.8M
VASCULAR, PULMONARY AND RENAL INJURYT32HL007627 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GIMBRONE, MICHAEL A, MITCHELL, RICHARD N · 1985 to 2019
$12.7M
NCATS NIH HHS UL1 TR001422NHLBI NIH HHS T32 HL007627
6 · The paper itself

Abstract

Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in ≤2% of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK inhibitors, which are among the first Food and Drug Administration-approved targeted therapies for NTRK-fused gliomas, has generated significant clinical interest in characterizing these tumors. In this multi-institutional retrospective study of 42 gliomas with NTRK fusions, next generation DNA sequencing (n = 41), next generation RNA sequencing (n = 1), RNA-sequencing fusion panel (n = 16), methylation profile analysis (n = 18), and histologic evaluation (n = 42) were performed. All infantile NTRK-fused gliomas (n = 7) had high-grade histology and, with one exception, no other significant genetic alterations. Pediatric NTRK-fused gliomas (n = 13) typically involved NTRK2, ranged from low- to high-histologic grade, and demonstrated histologic overlap with desmoplastic infantile ganglioglioma, pilocytic astrocytoma, ganglioglioma, and glioblastoma, among other entities, but they rarely matched with high confidence to known methylation class families or with each other; alterations involving ATRX, PTEN, and CDKN2A/2B were present in a subset of cases. Adult NTRK-fused gliomas (n = 22) typically involved NTRK1 and had predominantly high-grade histology; genetic alterations involving IDH1, ATRX, TP53, PTEN, TERT promoter, RB1, CDKN2A/2B, NF1, and polysomy 7 were common. Unsupervised principal component analysis of methylation profiles demonstrated no obvious grouping by histologic grade, NTRK gene involved, or age group. KEGG pathway analysis detected methylation differences in genes involved in PI3K/AKT, MAPK, and other pathways. In summary, the study highlights the clinical, histologic, and molecular heterogeneity of NTRK-fused gliomas, particularly when stratified by age group.

Indexed as

AdolescentAdultAgedAged, 80 and overBrain NeoplasmsChildChild, PreschoolFemaleGliomaHumansInfantMaleMiddle AgedOncogene Proteins, FusionReceptor, trkBRetrospective StudiesOncogene Proteins, FusionReceptor, trkBGliomaMethylationNGS sequencingNTRK

Identifiers

PMID32665022
PMCPMC7362646
OpenAlexW3042369616

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.