Evidence map›Paper›PMID 32665270›Full record

ArticlemBio2020

Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2.

Kristina Hopfensperger, Jonathan Richard, Christina M Stürzel, Frederic Bibollet-Ruche, Richard Apps, Marie Leoz, Jean-Christophe Plantier, Beatrice H Hahn, Andrés Finzi, Frank Kirchhoff and 1 more

Open access · goldAbstract read
In one paragraph

Article in mBio, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 4 countries.

Kristina HopfenspergerInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Jonathan RichardCentre de Recherche du CHUM, Montreal, Canada.
Christina M StürzelInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Frederic Bibollet-RucheDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Richard AppsNIH Center for Human Immunology, National Institutes of Health, Bethesda, Maryland, USA.
Marie LeozNormandie Université, UNIROUEN, UNICAEN, GRAM 2.0, Rouen, France.
Jean-Christophe PlantierNormandie Université, UNIROUEN, UNICAEN, GRAM 2.0, Rouen University Hospital, Department of Virology, Laboratory Associated with the National Reference Center on HIV, Rouen, France.
Beatrice H HahnDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Andrés FinziCentre de Recherche du CHUM, Montreal, Canada.
Frank KirchhoffInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany.
Daniel SauterInstitute of Molecular Virology, Ulm University Medical Center, Ulm, Germany daniel.sauter@uni-ulm.de.ORCID 0000-0001-7665-0040
Universität Ulm · DECentre Hospitalier de l’Université de Montréal · CANormandie Université · FRUniversity of Pennsylvania · USNational Institutes of Health · US

Funding

Virus & Reservoirs CoreP30AI045008 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Ronald G Collman · 1999 to 2026
$78.6M
Center for Human Immunology ZICAI001226 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI CHERRY, JAMES · 2018 to 2025
$34.1M
First-in-human study of two anti-SARS CoV-2 antibodies in health volunteersUM1AI126620 · NIAID · WISTAR INSTITUTE · PI MONTANER, LUIS J, RILEY, JAMES L. · 2016 to 2021
$24.5M
Optimizing glycan shield coverage, germline B cell receptor binding and epitope diversity of V2-apex targeted HIV-1 Env immunogensR37AI150590 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Beatrice H Hahn · 2019 to 2026
$6.9M
Natural SIV Reservoirs and Human Zoonotic RiskR01AI050529 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2001 to 2022
$6.1M
Studies of the precursor of the human AIDS virus in its natural chimpanzee hostR01AI120810 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2016 to 2020
$3.4M
Restriction of HIV-1 transmission by type 1 interferonsR01AI114266 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI HAHN, BEATRICE H · 2014 to 2018
$3.2M
NIAID NIH HHS P30 AI045008NIAID NIH HHS R01 AI050529NIAID NIH HHS R01 AI114266NIAID NIH HHS R01 AI120810NIAID NIH HHS R37 AI150590NIAID NIH HHS UM1 AI126620
6 · The paper itself

Abstract

HLA-C-mediated antigen presentation induces the killing of human immunodeficiency virus (HIV)-infected CD4

Indexed as

Evolution, MolecularCD4-Positive T-LymphocytesHEK293 CellsHIV-1HIV-2HIV InfectionsHLA-C AntigensHost-Pathogen InteractionsHuman Immunodeficiency Virus ProteinsHumansKiller Cells, NaturalT-Lymphocytes, Cytotoxicvif Gene Products, Human Immunodeficiency VirusViral Regulatory and Accessory ProteinsViroporin ProteinsHLA-C AntigensHuman Immunodeficiency Virus Proteinsvif Gene Products, Human Immunodeficiency Virusvif protein, Human immunodeficiency virus 2Viral Regulatory and Accessory ProteinsViroporin Proteinsvpu protein, Human immunodeficiency virus 1HIV-1HIV-2HLA-CSIVVifVpu

Identifiers

PMID32665270
PMCPMC7360927
OpenAlexW3043183789

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.