SynthesisBiological research for nursing2020
The Metabolomics of Chronic Pain Conditions: A Systematic Review.
Synthesis in Biological research for nursing, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Cold induced pain elicits reproducible breath metabolomic responses across geographically distinct populations.iScience · 2026Article
- Neurophysiological, Radiological, and Molecular Biomarkers of Pain-Related Conditions: An Umbrella Review.Journal of clinical medicine · 2026Review
- Metabolomics Reveals Reasons for the Efficacy of Acupuncture in Migraine Patients: The Role of Anaerobic Glycolysis and Mitochondrial Citrate in Migraine Relief.Phenomics (Cham, Switzerland) · 2025Article
- Exploring salivary metabolites as biomarkers in chronic craniofacial and orofacial pain: a metabolomic analysis.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Review
- Altered aminoacid and lipid metabolism in a rat orofacial inflammation model determined by omics approach: potential role in trigeminal sensitisation.The journal of headache and pain · 2025Article
- Salivary Metabolomics as a Diagnostic Tool: Distinct Metabolic Profiles Across Orofacial Pain Subtypes.International journal of molecular sciences · 2025Article
- Effects of patent foramen ovale in migraine: a metabolomics-based study.The Journal of physiology · 2025Article
- Carnitine and Other Metabolites in Fibromyalgia a Clinical Perspective on a Mendelian Randomization Study.Journal of pain research · 2025Article
- Hyperalgesic Priming in the Transition From Acute to Chronic Pain: Focus on Different Models and the Molecular Mechanisms Involved.Journal of pain research · 2025Review
- Chronic Overlapping Pain Conditions and Nociplastic Pain.medRxiv : the preprint server for health sciences · 2024Article
- Tetraspanin profiles of serum extracellular vesicles reflect functional limitations and pain perception in knee osteoarthritis.Arthritis research & therapy · 2024Article
- Article
- A new perspective of frozen shoulder pathology; the interplay between the brain and the immune system.Frontiers in physiology · 2024Review
- Assessing the Genetic Causal Effects Between Blood Metabolites and Spinal Pain: A Bidirectional Two-Sample Mendelian Randomization Study.Journal of pain research · 2024Article
- Predictive Ability of Serum Amino Acid Levels to Differentiate Fibromyalgia Patients from Healthy Subjects.Molecular diagnosis & therapy · 2024Article
- Association between preoperative serum C-reactive protein level and leukocyte count and postoperative pain after otolaryngological surgery.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- WouldJournal of personalized medicine · 2023Article
- Article
- Lipidomic Profiling Identifies Serum Lipids Associated with Persistent Multisite Musculoskeletal Pain.Metabolites · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
backgroundChronic pain is a significant public health problem in the United States, affecting approximately 100 million people. Yet there is a lack of robust biomarkers for clinical use in chronic pain conditions. Downstream effects of environmental, genomic, and proteomic variations in individuals with chronic pain conditions can be identified and quantified using a metabolomic approach. AIM/
designThe purpose of this systematic review was to examine the literature for reports of potential metabolomic signatures associated with chronic pain conditions.
methodsWe searched relevant electronic databases for published studies that used various metabolomic approaches to investigate chronic pain conditions among subjects of all ages.
resultsOur search identified a total of 586 articles, 18 of which are included in this review. The reviewed studies used metabolomics to investigate fibromyalgia (
conclusionThough more high-quality research is needed, this review provides insights into potential biomarkers for future metabolomics studies in people with chronic pain conditions.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.