Evidence map›Paper›PMID 32667736›Full record

ArticleESC heart failure2020

Evaluation of left ventricular function in patients with acute ischaemic stroke using cine cardiovascular magnetic resonance imaging.

Simon Hellwig, Ulrike Grittner, Matthias Elgeti, Sebastian Wyschkon, Sebastian N Nagel, Jochen B Fiebach, Thomas Krause, Juliane Herm, Jan F Scheitz, Matthias Endres and 3 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ESC heart failure, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02142413 (HEart and BRain Interfaces in Acute Ischemic Stroke), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02142413 completednot on this map

HEart and BRain Interfaces in Acute Ischemic Stroke (HEBRAS) - A Prospective Oberservational Cohort Study

TypeobservationalSponsorCharite University, Berlin, GermanyRan2014 to 2018Enrolled368ConditionsStroke, Atrial Fibrillation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Unravelling the role of electrocardiogram changes and ejection fraction in ischaemic stroke outcomes.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2025
    Review
  3. Review
  4. Review
  5. Observational
  6. Stroke-Heart Syndrome: Recent Advances and Challenges.Journal of the American Heart Association · 2022
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Simon HellwigDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-6925-4768
Ulrike GrittnerInstitute of Biometry and Clinical Epidemiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Matthias ElgetiJules Stein Eye Institute and Department for Chemistry and Biochemistry, University of California, Los Angeles, CA, USA.
Sebastian WyschkonDepartment of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Sebastian N NagelDepartment of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Jochen B FiebachCentre for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Thomas KrauseDepartment of Neurology, Jüdisches Krankenhaus Berlin, Berlin, Germany.
Juliane HermDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Jan F ScheitzDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Matthias EndresDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Christian H NolteDepartment of Neurology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Karl Georg HaeuslerDepartment of Neurology, Universitätsklinikum Würzburg, Würzburg, Germany.
Thomas ElgetiDepartment of Radiology, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Charité - Universitätsmedizin Berlin · DEGerman Center for Neurodegenerative Diseases · DEGerman Centre for Cardiovascular Research · DEJüdisches Krankenhaus Berlin · DEUniversitätsklinikum Würzburg · DEUniversity of California, Los Angeles · USZimmer Biomet (Germany) · DE

Funding

German Federal Ministry of Education and Research 01 EO 0801
6 · The paper itself

Abstract

aimsHeart failure (HF) is frequent in patients with acute ischaemic stroke (AIS) and associated with higher morbidity and mortality. Assessment of cardiac function in AIS patients using cardiovascular MRI (CMR) may help to detect HF. We report the rate of systolic and diastolic dysfunction in a cohort of patients with AIS using CMR and compare cine real-time (CRT) sequences with the reference of segmented cine steady-state free precession sequences. METHODS AND

resultsPatients with AIS without known atrial fibrillation were prospectively enrolled in the HEart and BRain Interfaces in Acute Ischemic Stroke (HEBRAS) study (NCT02142413) and underwent CMR at 3 Tesla within 7 days after AIS. Validity of CRT sequences was determined in 50 patients. A total of 229 patients were included in the analysis (mean age 66 years; 35% women; HF 2%). Evaluation of cardiac function was successful in 172 (75%) patients. Median time from stroke onset to CMR was 82 h (interquartile range 56-111) and 54 h (interquartile range 31-78) from cerebral MRI to CMR. Systolic dysfunction was observed in 43 (25%) and diastolic dysfunction in 102 (59%) patients. Diagnostic yield was similar using CRT or segmented cine imaging (no significant difference in left ventricular ejection fraction, myocardial mass, time to peak filling rate, and peak filling rate ratio E/A). Intraobserver and interobserver agreement was high (κ = 0.78-1.0 for all modalities).

conclusionsCardiovascular MRI at 3 Tesla is an appropriate method for the evaluation of cardiac function in a selected cohort of patients with AIS. Systolic and diastolic dysfunction is frequent in these patients. CRT imaging allows reliable assessment of systolic and diastolic function.

Indexed as

Brain IschemiaIschemic StrokeStrokeAgedFemaleHumansMagnetic Resonance ImagingMaleStroke VolumeVentricular Function, LeftAcute ischaemic strokeCardiac MRICine real-timeDiastolic dysfunctionHeart failureVolume-time curve

Identifiers

PMID32667736
PMCPMC7524103
OpenAlexW3043815852

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.