Evidence map›Paper›PMID 32668765›Full record

ArticleCells2020

Loss of Function of the Gene Encoding the Histone Methyltransferase KMT2D Leads to Deregulation of Mitochondrial Respiration.

Consiglia Pacelli, Iolanda Adipietro, Natascia Malerba, Gabriella Maria Squeo, Claudia Piccoli, Angela Amoresano, Gabriella Pinto, Pietro Pucci, Ji-Eun Lee, Kai Ge and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 19 citations in OpenAlex.

  1. Trial
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  9. American journal of cancer research · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Consiglia PacelliDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy.ORCID 0000-0003-4915-5823
Iolanda AdipietroDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (FG), Italy.
Natascia MalerbaDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (FG), Italy.
Gabriella Maria SqueoDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (FG), Italy.
Claudia PiccoliDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy.
Angela AmoresanoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Napoli, Italy.
Gabriella PintoDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Napoli, Italy.
Pietro PucciDepartment of Chemical Sciences, University of Naples "Federico II", 80126 Napoli, Italy.
Ji-Eun LeeNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Kai GeNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Nazzareno CapitanioDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, Italy.
Giuseppe MerlaDivision of Medical Genetics, Fondazione IRCCS Casa Sollievo della Sofferenza, 71013 San Giovanni Rotondo (FG), Italy.ORCID 0000-0001-5078-928X
Casa Sollievo della Sofferenza · ITFederico II University Hospital · ITUniversity of Foggia · ITNational Institutes of Health · US

Funding

Regulation of PPARgamma Expression and Adipogenesis by PTIP-Associated FactorsZIADK075003 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI GE, KAI · 2009 to 2025
$17.6M
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsCell RespirationDNA-Binding ProteinsDown-RegulationElectron Transport Chain Complex ProteinsFatty AcidsFibroblastsGlucoseGlycolysisHistone-Lysine N-MethyltransferaseHomeostasisHumansLoss of Function MutationMembrane Potential, MitochondrialMetabolic Flux AnalysisMiceDNA-Binding ProteinsElectron Transport Chain Complex ProteinsFatty AcidsGlucoseHistone-Lysine N-MethyltransferaseKMT2D protein, humanKmt2d protein, mouseMyeloid-Lymphoid Leukemia ProteinNeoplasm ProteinsReactive Oxygen SpeciesKabuki syndromeKMT2Dmitochondria

Identifiers

PMID32668765
PMCPMC7407568
OpenAlexW3041090878

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.