Evidence map›Paper›PMID 32675281›Full record

SynthesisClinical journal of the American Society of Nephrology : CJASN2020

Comparative Efficacy and Safety of BP-Lowering Pharmacotherapy in Patients Undergoing Maintenance Dialysis: A Network Meta-Analysis of Randomized, Controlled Trials.

Ahmed M Shaman, Brendan Smyth, Clare Arnott, Suetonia C Palmer, Anastasia S Mihailidou, Meg J Jardine, Martin P Gallagher, Vlado Perkovic, Min Jun

Open access · greenAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Clinical journal of the American Society of Nephrology : CJASN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it, 11 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Guideline
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 3 countries.

Ahmed M ShamanThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
Brendan SmythThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.ORCID 0000-0003-1838-3348
Clare ArnottThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
Suetonia C PalmerDepartment of Medicine, University of Otago Christchurch, Christchurch, New Zealand.
Anastasia S MihailidouDepartment of Cardiology and Kolling Institute, Northern Sydney Local Health District, St. Leonards, New South Wales, Australia.
Meg J JardineThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
Martin P GallagherThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
Vlado PerkovicThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
Min JunThe George Institute for Global Health, Faculty of Medicine, The University of New South Wales, Sydney, New South Wales, Australia.
The University of Sydney · AUUNSW Sydney · AUConcord Repatriation General Hospital · AUKing Saud University · SANorthern Sydney Local Health District · AURoyal Prince Alfred Hospital · AUUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesElevated BP is an important risk factor for cardiovascular disease, with a prevalence of over 80% in patients undergoing maintenance dialysis. We assessed the comparative BP-lowering efficacy and the safety of BP-lowering drugs in patients undergoing maintenance dialysis. DESIGN, SETTINGS, PARTICIPANTS, & MEASUREMENTS: We performed a frequentist random effects network meta-analysis of randomized, controlled trials evaluating BP-lowering agents in adult patients undergoing maintenance dialysis. Electronic databases (CENTRAL, MEDLINE, and Embase) were systematically searched (up to August 2018) for relevant trials. The main outcome was systolic BP reduction.

resultsForty trials (4283 participants) met our inclusion criteria. Angiotensin-converting enzyme inhibitors,

conclusionsBP-lowering agents significantly reduced systolic BP in patients undergoing maintenance dialysis.

Indexed as

AdultAgedAntihypertensive AgentsBlood PressureComparative Effectiveness ResearchFemaleHumansHypertensionKidneyMaleMiddle AgedRandomized Controlled Trials as TopicRenal Insufficiency, ChronicTime FactorsTreatment OutcomeAntihypertensive AgentsAdverse eventsAngiotensin-Converting Enzyme InhibitorsAngiotensin Receptor AntagonistsAntihypertensive agentsblood pressureCalcium Channel BlockersCardiovascular Diseaseschronic kidney diseasehypertensionhypotensionMineralocorticoid Receptor AntagonistsPeptidyl-Dipeptidase Arenal dialysisReninrisk factorssystolic blood pressure

Identifiers

PMID32675281
PMCPMC7409758
OpenAlexW3042689707

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.