Evidence map›Paper›PMID 32675284›Full record

ArticleThe Journal of biological chemistry2020

Caspr2 interacts with type 1 inositol 1,4,5-trisphosphate receptor in the developing cerebellum and regulates Purkinje cell morphology.

Liam Argent, Friederike Winter, Imogen Prickett, Maria Carrasquero-Ordaz, Abby L Olsen, Holger Kramer, Eric Lancaster, Esther B E Becker

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Liam ArgentDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-2457-248X
Friederike WinterDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Imogen PrickettDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.
Maria Carrasquero-OrdazDepartment of Biochemistry, University of Oxford, Oxford, United Kingdom.
Abby L OlsenDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-7680-1758
Holger KramerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom.ORCID 0000-0002-6400-0945
Eric LancasterDepartment of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.
Esther B E BeckerDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, United Kingdom esther.becker@dpag.ox.ac.uk.ORCID 0000-0002-5238-4902
University of Oxford · GBUniversity of Pennsylvania · US

Funding

Wellcome TrustWellcome Trust 096585/Z/11/Z
6 · The paper itself

Abstract

Contactin-associated protein-like 2 (Caspr2) is a neurexin-like protein that has been associated with numerous neurological conditions. However, the specific functional roles that Caspr2 plays in the central nervous system and their underlying mechanisms remain incompletely understood. Here, we report on a functional role for Caspr2 in the developing cerebellum. Using a combination of confocal microscopy, biochemical analyses, and behavioral testing, we show that loss of Caspr2 in the

Indexed as

AnimalsHEK293 CellsHumansInositol 1,4,5-Trisphosphate ReceptorsMembrane ProteinsMiceMice, KnockoutNerve Tissue ProteinsProtein DomainsPurkinje CellsCNTNAP2 protein, mouseInositol 1,4,5-Trisphosphate ReceptorsItpr1 protein, mouseMembrane ProteinsNerve Tissue ProteinscalciumCaspr2cerebellumCntnap2dendritedevelopmentinositol 1,4,5-trisphosphate (IP3)inositol trisphosphate receptor (InsP3R)Purkinje cellsynapse

Identifiers

PMID32675284
PMCPMC7476715
OpenAlexW3042281281

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.