Evidence mapPaperPMID 32676844Full record

ArticleObesity surgery2020

Continuous Glucose Monitoring of Glycemic Variability During Fasting Post-Sleeve Gastrectomy.

Ebaa Al-Ozairi, Abeer El Samad, Jumana Al Kandari, Etab Taghadom, Safwaan Adam, Carel le Roux, Akheel A Syed

Open access · hybridAbstract read
In one paragraph

Article in Obesity surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Ebaa Al-OzairiClinical Research Unit, Medical Division, Dasman Diabetes Institute, P.O. Box 1180, 15462, Dasman, Kuwait. ebaa.alozairi@dasmaninstitute.org.ORCID 0000-0001-5006-4369
Abeer El SamadClinical Research Unit, Medical Division, Dasman Diabetes Institute, P.O. Box 1180, 15462, Dasman, Kuwait.
Jumana Al KandariClinical Research Unit, Medical Division, Dasman Diabetes Institute, P.O. Box 1180, 15462, Dasman, Kuwait.
Etab TaghadomClinical Research Unit, Medical Division, Dasman Diabetes Institute, P.O. Box 1180, 15462, Dasman, Kuwait.
Safwaan AdamDepartment of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, Manchester, UK.ORCID 0000-0001-8004-1897
Carel le RouxDiabetes Complications Research Centre, University College Dublin, Dublin, Ireland.ORCID 0000-0001-5521-5445
Akheel A SyedDepartment of Diabetes, Endocrinology and Obesity Medicine, Salford Royal NHS Foundation Trust and University Teaching Hospital, Salford, Manchester, UK.ORCID 0000-0001-8696-7121
Dasman Diabetes Institute · KWSalford Royal NHS Foundation Trust · GBKuwait University · KWUniversity College Dublin · IE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDay-long fasting creates considerable metabolic stress that poses challenges in people with diabetes and those who have undergone bariatric surgery. Clinical knowledge of glucose fluctuations and the risks for such patients during fasting is limited.

objectivesThis study examined the effect of intermittent fasting on glucose excursions, hypoglycemia, and hyperglycemia in people with or without diabetes who had sleeve gastrectomy compared with healthy individuals.

methodsThis open-label, prospective study compared interstitial glucose profiles measured with continuous glucose monitoring system for 72 h during fasting and non-fasting periods between four groups comprising 15 participants each: people with obesity and medicine-treated type 2 diabetes (T2D) only, obesity and T2D treated with sleeve gastrectomy, obesity without T2D treated with sleeve gastrectomy, and healthy, normal-weight non-diabetic controls.

resultsThe mean 72-h glucose concentration was significantly lower during the fasting period for all groups (p ≤ 0.041), with the highest glucose concentrations in the medicine-treated T2D-only group and the lowest concentrations in the sleeve gastrectomy in non-T2D group. The mean glucose profiles of all the groups showed a marked increase in interstitial glucose on breaking the fast, which was exaggerated in the two diabetes groups. The mean amplitude of glycemic excursions did not differ significantly within each group between fasting and non-fasting. No significant difference was noted in the fraction of time in the hypoglycemic range between the fasting and non-fasting periods in any group.

conclusionIntermittent fasting had no adverse effect on glycemic control in people with or without diabetes who had undergone sleeve gastrectomy.

Indexed as

Diabetes Mellitus, Type 2Obesity, MorbidBlood GlucoseBlood Glucose Self-MonitoringFastingGastrectomyHumansProspective StudiesBlood GlucoseBariatric surgeryContinuous glucose monitoring systemFastingSleeve gastrectomyType 2 diabetes

Identifiers

PMID32676844
PMCPMC7467959
OpenAlexW3008303008

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.