Evidence map›Paper›PMID 32679229›Full record

ArticleThe American journal of pathology2020

Lacrimal Gland Myoepithelial Cells Are Altered in a Mouse Model of Dry Eye Disease.

Laura García-Posadas, Robin R Hodges, Tor P Utheim, Ole Kristoffer Olstad, Vanessa Delcroix, Helen P Makarenkova, Darlene A Dartt

Open access · bronzeAbstract read
In one paragraph

Article in The American journal of pathology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  8. The βAdvances in pharmacological and pharmaceutical sciences · 2024
    Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Obstructive Sleep Apnea Affects Lacrimal Gland Function.Investigative ophthalmology & visual science · 2022
    Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Mouse Models of Sjögren's Syndrome with Ocular Surface Disease.International journal of molecular sciences · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Laura García-PosadasSchepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Robin R HodgesSchepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts.
Tor P UtheimSchepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts; Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway; Plastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.
Ole Kristoffer OlstadPlastic and Reconstructive Surgery, Oslo University Hospital, Oslo, Norway.
Vanessa DelcroixDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California.
Helen P MakarenkovaDepartment of Molecular Medicine, The Scripps Research Institute, La Jolla, California.
Darlene A DarttSchepens Eye Research Institute/Massachusetts Eye and Ear, Harvard Medical School, Boston, Massachusetts; Department of Ophthalmology, Harvard Medical School, Boston, Massachusetts. Electronic address: darlene_dartt@meei.harvard.edu.
Massachusetts Eye and Ear Infirmary · USOslo University Hospital · NOScripps Research Institute · US

Funding

Lacrimal Gland Repair Using Progenitor CellsR01EY026202 · NEI · SCRIPPS RESEARCH INSTITUTE, THE · PI MAKARENKOVA, HELEN P. · 2016 to 2025
$5.2M
NEI NIH HHS R01 EY026202
6 · The paper itself

Abstract

The purpose of this study was to determine the pathogenic changes that occur in myoepithelial cells (MECs) from lacrimal glands of a mouse model of Sjögren syndrome. MECs were cultured from lacrimal glands of C57BL/6J [wild type (WT)] and thrombospondin 1 null (TSP1

Indexed as

AnimalsCalciumCalcium SignalingDisease Models, AnimalDry Eye SyndromesEpithelial CellsInflammationMice, Inbred C57BLMuscle CellsMuscle, SmoothCalcium

Identifiers

PMID32679229
PMCPMC7520664
OpenAlexW3042681395

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.