Evidence map›Paper›PMID 32679915›Full record

ReviewInternational journal of molecular sciences2020

Gestational Diabetes Mellitus: A Harbinger of the Vicious Cycle of Diabetes.

Emilyn U Alejandro, Therriz P Mamerto, Grace Chung, Adrian Villavieja, Nawirah Lumna Gaus, Elizabeth Morgan, Maria Ruth B Pineda-Cortel

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 164 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
164citing papers in PubMed, 11 pooled it
13.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

164 citing papers in PubMed, 11 syntheses or guidelines pooled it, 324 citations in OpenAlex.

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104 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Emilyn U AlejandroDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Therriz P MamertoResearch Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines.ORCID 0000-0002-3466-891X
Grace ChungDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Adrian VillaviejaResearch Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines.
Nawirah Lumna GausThe Graduate School, University of Santo Tomas, Manila 1015, Philippines.
Elizabeth MorganBaystate Medical Center, Baystate Health, Springfield, MA 01199, USA.
Maria Ruth B Pineda-CortelResearch Center for the Natural and Applied Sciences, University of Santo Tomas, Manila 1015, Philippines.ORCID 0000-0001-6157-7012
University of Santo Tomas · PHUniversity of Minnesota Medical Center · USBaystate Medical Center · US

Funding

The role of O-linked N-Acetylglucosamine Homeostasis in Pancreatic Beta-cell Development and FunctionR01DK115720 · NIDDK · UNIVERSITY OF MINNESOTA · PI ALEJANDRO, EMILYN · 2018 to 2022
$1.9M
O-linked-N-acetylglucosamine Post-translational Modification in Pancreatic Beta-cells Regulating ER Stress and Mitochondrial FunctionR21DK112144 · NIDDK · UNIVERSITY OF MINNESOTA · PI ALEJANDRO, EMILYN · 2017 to 2019
$576k
Innate Immune Complement System and Developmental Programming of Functional β Cell MassR21HD100840 · NICHD · UNIVERSITY OF MINNESOTA · PI ALEJANDRO, EMILYN, REGAL, JEAN F. · 2020 to 2021
$425k
Role of placental nutrient-sensor protein mTOR on fetal programming of beta-cell dysfunction and susceptibility to type 2 diabetesR03DK114465 · NIDDK · UNIVERSITY OF MINNESOTA · PI ALEJANDRO, EMILYN · 2018 to 2019
$360k
NICHD NIH HHS R21 HD100840NIDDK NIH HHS R01 DK115720NIDDK NIH HHS R03 DK114465NIDDK NIH HHS R21 DK112144NIH HHS R21DK-112144, R03-DK114465, R01-DK115720
6 · The paper itself

Abstract

Gestational diabetes mellitus (GDM), characterized by a transitory form of diabetes induced by insulin resistance and pancreatic β-cell dysfunction during pregnancy, has been identified as one of the major obstacles in achieving improved maternal and child health. Approximately 9-25% of pregnancies worldwide are impacted by the acute, long-term, and transgenerational health complications of this disease. Here, we discuss how GDM affects longstanding maternal and neonatal outcomes, as well as health risks that likely persist into future generations. In addition to the current challenges in the management and diagnosis of and the complications associated with GDM, we discuss current preclinical models of GDM to better understand the underlying pathophysiology of the disease and the timely need to increase our scientific toolbox to identify strategies to prevent and treat GDM, thereby advancing clinical care.

Indexed as

AnimalsDiabetes, GestationalDiabetes Mellitus, ExperimentalDisease Models, AnimalFemaleGenetic Predisposition to DiseaseHumansInfant, NewbornMass ScreeningPregnancyRisk FactorsSocioeconomic Factorsdiabetes animal modelsfetal programminggestational diabetes mellitus and diabetesglycemic controlhyperglycemiainsulinobesityplacentapolycystic ovary syndromepregnancy complicationstype 2 diabetes

Identifiers

PMID32679915
PMCPMC7404253
OpenAlexW3043637524

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.