Evidence map›Paper›PMID 32680935›Full record

ArticleDevelopment (Cambridge, England)2020

Prdm8 regulates pMN progenitor specification for motor neuron and oligodendrocyte fates by modulating the Shh signaling response.

Kayt Scott, Rebecca O'Rourke, Austin Gillen, Bruce Appel

Open access · bronzeAbstract read
In one paragraph

Article in Development (Cambridge, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 23 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kayt ScottDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 40045, USA.
Rebecca O'RourkeDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 40045, USA.
Austin GillenRNA Bioscience Initiative, University of Colorado School of Medicine, Aurora, Colorado 40045, USA.
Bruce AppelDepartment of Pediatrics, Section of Developmental Biology, University of Colorado School of Medicine, Aurora, Colorado 40045, USA bruce.appel@cuanschutz.edu.ORCID 0000-0003-4500-0672
University of Colorado Denver · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
ZEBRAFISH TRANSGENIC CORE - ROCKY MOUNTAIN NEUROLOGICAL DISORDERS CORE CENTERP30NS048154 · NINDS · UNIVERSITY OF COLORADO DENVER · PI RIBERA, ANGELES BADELL · 2004 to 2020
$10.1M
Genetic Analysis of Oligodendrocyte SpecificationR01NS046668 · NINDS · VANDERBILT UNIVERSITY · PI APPEL, BRUCE H · 2004 to 2019
$4.8M
NCI NIH HHS P30 CA046934NINDS NIH HHS P30 NS048154NINDS NIH HHS R01 NS046668
6 · The paper itself

Abstract

Spinal cord pMN progenitors sequentially produce motor neurons and oligodendrocyte precursor cells (OPCs). Some OPCs differentiate rapidly as myelinating oligodendrocytes, whereas others remain into adulthood. How pMN progenitors switch from producing motor neurons to OPCs with distinct fates is poorly understood. pMN progenitors express

Indexed as

Cell DifferentiationSignal TransductionAnimalsDNA-Binding ProteinsHedgehog ProteinsHistone MethyltransferasesMiceMice, TransgenicMotor NeuronsNeural Stem CellsOligodendrogliaDNA-Binding ProteinsHedgehog ProteinsHistone MethyltransferasesPRDM8 protein, mouseShh protein, mouseMotor neuronsOligodendrocytespMN progenitorsSonic hedgehogSpinal cordZebrafish

Identifiers

PMID32680935
PMCPMC7473643
OpenAlexW3043040754

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.