ArticleOxidative medicine and cellular longevity2020
Oxidative Stress Markers Differ in Two Placental Dysfunction Pathologies: Pregnancy-Induced Hypertension and Intrauterine Growth Restriction.
Article in Oxidative medicine and cellular longevity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Oxidative stress biomarkers in fetal growth restriction: a systematic review and meta-analysis.Archives of gynecology and obstetrics · 2025Pooled it
- Oxidative stress biomarkers in pregnancy: a systematic review.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Pooled it
- Article
- Longitudinal inflammatory biomarker profiling in intrauterine growth restricted preterm infants.Cytokine · 2025Article
- Maternal exposure to fullerenols impairs placental development in mice by inhibiting estriol synthesis and reducing ERα.Journal of nanobiotechnology · 2025Article
- An assessment of total antioxidant and oxidant parameters and their correlation with embryo quality in in-vitro fertilization patients.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- The Applicability and Limitations of the Spectrofluorometric Method for Determination of ALDH1 Activity in Serum and Plasma.Diagnostics (Basel, Switzerland) · 2024Article
- Allostatic Load and Oxidative Stress Markers in Women With Early- and Late-Onset Preeclampsia.Cureus · 2024Article
- The Importance of Metabolic and Environmental Factors in the Occurrence of Oxidative Stress during Pregnancy.International journal of molecular sciences · 2023Review
- The impact of dental metal restorations on the oral oxidative stress level.Journal of clinical and experimental dentistry · 2023Article
- Placental morphological features of small for gestational age preterm neonates born to mothers with pregnancy-induced hypertension.Frontiers in pediatrics · 2023Article
- Markers of Oxidative Stress in Obstetrics and Gynaecology-A Systematic Literature Review.Antioxidants (Basel, Switzerland) · 2022Review
- Malondialdehyde and Neutrophil Gelatinase-Associated Lipocalin as Markers of Oxidative Stress in Small for Gestational Age Newborns from Hypertensive and Preeclamptic Pregnancies.BioMed research international · 2022Article
- Endothelial dysfunction in preterm infants: The hidden legacy of uteroplacental pathologies.Frontiers in pediatrics · 2022Review
- Glutathione and oxidized nicotinamide adenine dinucleotide (NADSaudi medical journal · 2021Article
- Considering intrauterine location in a model of fetal growth restriction after maternal titanium dioxide nanoparticle inhalation.Frontiers in toxicology · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimPregnancy-induced hypertension (PIH) and intrauterine growth restriction (IUGR) are both multisystemic disorders of pregnancy that cause perinatal morbidity and mortality. Recently, researchers focused on the role of oxidative stress (OS) as a pathophysiological mechanism in the development of these pathologies. The aim of this study was to compare OS in placental-related pathologies (PIH and IUGR) and uncomplicated pregnancies. We also investigated which salivary OS markers reflect systemic oxidative status and which only reflect the state of the oral cavity.
resultsIn the IUGR group, increased concentration of ORAC was observed both in saliva and plasma. Also, lower plasma levels of MDA in IUGR compared to the control group was detected. No sign of oxidative stress was confirmed in the PIH group. The examined groups did not differ regarding diet and markers of inflammation. ORAC in saliva was correlated with its level in plasma. No such correlations for MDA were observed. In the IUGR group, there were no differences in OS markers in plasma, but there was a lower ALDH level in the blood compared to the control group. It confirms OS occurrence in IUGR. In IUGR, a higher activity of salivary ALDH was probably due to worse oral health.
conclusionOxidative stress differs between IUGR and PIH groups: the presence of oxidative stress was confirmed only in the IUGR group. Salivary ORAC can be used to estimate ORAC in plasma. The activity of salivary ALDH reflects the state of the oral cavity.
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