ArticleAutophagy2021
SETX (senataxin), the helicase mutated in AOA2 and ALS4, functions in autophagy regulation.
Open access · bronzeAbstract read
In one paragraph
Article in Autophagy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 2 pooled it
5.2field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Ataxia with oculomotor apraxia type 2: two pedigree studies and a comprehensive review.Journal of neurology · 2025Pooled it
- C9orf72-related amyotrophic lateral sclerosis-frontotemporal dementia and links to the DNA damage response: a systematic review.Frontiers in molecular neuroscience · 2025Pooled it
- The DNA/RNA Helicase SETX Maintains R-Loop Homeostasis to Promote Chemoresistance in Ovarian Cancer.Cancer science · 2026Article
- When R-Loops Go Awry: Genome Instability and Neurological Diseases.The European journal of neuroscience · 2026Review
- Wild-typemedRxiv : the preprint server for health sciences · 2026Article
- Evidence of an unprecedented cytoplasmic function of DDX11, the Warsaw breakage syndrome DNA helicase, in regulating autophagy.Autophagy · 2025Article
- Update on R-loops in genomic integrity: Formation, functions, and implications for human diseases.Genes & diseases · 2025Review
- Transcription-Coupled Repair and R-Loop Crosstalk in Genome Stability.International journal of molecular sciences · 2025Review
- Senataxin prevents replicative stress induced by the Myc oncogene.Cell death & disease · 2025Article
- Comparative genomics uncovers evolutionary drivers of locust migratory adaptation.BMC genomics · 2025Article
- Development of a Prognostic Risk Model Based on Oxidative Stress-related Genes for Platinum-resistant Ovarian Cancer Patients.Recent patents on anti-cancer drug discovery · 2025Article
- Annotation and functional prediction of RNA helicases inIMA fungus · 2025Review
- Mechanisms underlining R-loop biology and implications for human disease.Frontiers in cell and developmental biology · 2025Review
- Regulation of DNA damage response by RNA/DNA-binding proteins: Implications for neurological disorders and aging.Ageing research reviews · 2024Review
- R-loops and impaired autophagy trigger cGAS-dependent inflammation via micronuclei formation in Senataxin-deficient cells.Cellular and molecular life sciences : CMLS · 2024Article
- Senataxin deficiency disrupts proteostasis through nucleolar ncRNA-driven protein aggregation.The Journal of cell biology · 2024Article
- TPX2 upregulates MMP13 to promote the progression of lipopolysaccharide-induced osteoarthritis.PeerJ · 2024Article
- Role of senataxin in R-loop-mediated neurodegeneration.Brain communications · 2024Review
- Role of Senataxin in Amyotrophic Lateral Sclerosis.Journal of molecular neuroscience : MN · 2023Review
- Glc7/PP1 dephosphorylates histone H3T11 to regulate autophagy and telomere silencing in response to nutrient availability.Cell discovery · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
18 authors at 8 institutions in 3 countries.
Patricia RichardDepartment of Biological Sciences, Columbia University, New York, NY, USA.ORCID 0000-0002-9515-4509
Shuang Feng
Yueh-Lin TsaiDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Wencheng LiDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.
Paola RinchettiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0001-8279-3304
Ubayed MuhithDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Juan Irizarry-ColeDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Katharine StolzDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Lionel A SanzDepartment of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA.
Stella HartonoDepartment of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA.
Mainul HoqueDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.
Saba TadesseDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Hervé SeitzInstitut de Génétique Humaine, UMR 9002 CNRS and Université de Montpellier, Montpellier, France.ORCID 0000-0001-8172-5393
Francesco LottiDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.ORCID 0000-0002-5104-9088
Michio HiranoDepartment of Neurology, Columbia University Irving Medical Center, New York, NY, USA.
Frédéric ChédinDepartment of Molecular and Cellular Biology and Genome Center, University of California, Davis, CA, USA.ORCID 0000-0002-1306-5335
Bin TianDepartment of Microbiology, Biochemistry and Molecular Genetics, Rutgers New Jersey Medical School, Newark, NJ, USA.ORCID 0000-0001-8903-8256
James L ManleyDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Columbia University · USColumbia University Irving Medical Center · USUniversity of California, Davis · USRutgers, The State University of New Jersey · USCentre National de la Recherche Scientifique · FRStella Therapeutics (United States) · USThe Wistar Institute · USUniversity of Milan · IT
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Aaron Robert Goldman · 1985 to 2026
$75.9MRegulation of RNA processing: Mechanisms and ConsequencesR35GM118136 · NIGMS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI James L. Manley · 2016 to 2026
$8.9MRegulation of Alternative Cleavage and PolyadenylationR01GM084089 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2008 to 2023
$6.7MRegulation and Functions of 3'UTRs in Cellular StressR01GM129069 · NIGMS · WISTAR INSTITUTE · PI TIAN, BIN · 2018 to 2021
$1.5MGenomic profiling of pathological R-loop formation in human diseases.R01GM120607 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI CHEDIN, FREDERIC LOUIS · 2016 to 2019
$1.2MSMN post-translational modification in Spinal Muscular AtrophyR21NS101575 · NINDS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LOTTI, FRANCESCO · 2017 to 2018
$440kNCI NIH HHS P30 CA010815NIGMS NIH HHS R01 GM084089NIGMS NIH HHS R01 GM120607NIGMS NIH HHS R01 GM129069NIGMS NIH HHS R35 GM118136NINDS NIH HHS R21 NS101575
Abstract
SETX (senataxin) is an RNA/DNA helicase that has been implicated in transcriptional regulation and the DNA damage response through resolution of R-loop structures. Mutations in
Indexed as
Amyotrophic Lateral SclerosisAutophagyDNA HelicasesGene Expression RegulationHumansMotor NeuronsMultifunctional EnzymesRNA HelicasesDNA HelicasesMultifunctional EnzymesRNA HelicasesSETX protein, humanAOA2autophagyDRIPLC3lysosomal degradationR loopR-loopsenataxinSETXtranscription regulation
Identifiers
What Socratic holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.