Trial reportAmerican journal of obstetrics and gynecology2021
Weight loss prior to pregnancy and subsequent gestational weight gain: Prepare, a randomized clinical trial.
Trial report in American journal of obstetrics and gynecology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02346162 (PREPARE), which is not on this map. Cited by 37 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
PREPARE: A Randomized Trial of a Pre-pregnancy Weight Loss Intervention
Who cites it
37 citing papers in PubMed, 8 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- 2026 AHA/ACC/ADA/ASN Guideline for the Prevention, Detection, Evaluation, and Management of Cardiovascular-Kidney-Metabolic Syndrome: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines.Journal of the American College of Cardiology · 2026Guideline
- Preconception Interventions in Women at High Risk of Developing Gestational Diabetes: A Systematic Review.Maternal and child health journal · 2026Pooled it
- Preconception lifestyle interventions for women-a systematic review and meta-analysis of intervention characteristics and behaviour change techniques.Human reproduction update · 2026Pooled it
- Do dietary interventions aimed at enhancing fertility improve nutritional status in overweight or obese women?Asia Pacific journal of clinical nutrition · 2025Pooled it
- Association of Digital Health Interventions With Maternal and Neonatal Outcomes: Systematic Review and Meta-Analysis.Journal of medical Internet research · 2025Pooled it
- Effectiveness of preconception weight loss interventions on fertility in women: a systematic review and meta-analysis.Fertility and sterility · 2024Pooled it
- Effectiveness of preconception interventions in primary care: a systematic review.The British journal of general practice : the journal of the Royal College of General Practitioners · 2022Pooled it
- Preconception and periconception interventions to prevent low birth weight, small for gestational age and preterm birth: a systematic review and meta-analysis.BMJ global health · 2022Pooled it
- No Effect of Prepregnancy Weight Loss Intervention on Child Weight up to Age 5.Childhood obesity (Print) · 2026Trial
- Trial
- Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING).BMJ (Clinical research ed.) · 2025Trial
- Acceptability and feasibility of a planned preconception weight loss intervention in women with long-acting reversible contraception: the Plan-it mixed-methods study.Health technology assessment (Winchester, England) · 2023Trial
- Weight Loss Prior to Pregnancy and Early Gestational Glycemia: Prepare, a Randomized Clinical Trial.The Journal of clinical endocrinology and metabolism · 2021Trial
- Glucagon-Like Peptide-1 Receptor Agonists: Considerations for Treating Preconception Obesity.Obesity (Silver Spring, Md.) · 2026Article
- Maternal cardiometabolic health and the role of GLP-1 receptor agonists from preconception to postpartum: A review of evidence and opportunities.American journal of preventive cardiology · 2026Review
- Preconception Weight Loss to Prevent Childhood Obesity: Current Evidence and Research Gaps.Current obesity reports · 2026Review
- Weight management in women of reproductive age.Obesity and endocrinology · 2026Review
- Functional disability mediates the relationship between pain severity and quality of life in pregnant women with pregnancy-related low back pain: a moderated mediation analysis.BMC pregnancy and childbirth · 2025Article
- The effect of maternal pre-pregnancy body mass index on hypertensive disorders of pregnancy (HDP): a systematic review and dose-response meta-analysis of cohort studies involving 50 million pregnancies.EClinicalMedicine · 2025Article
- A systematic review of behavioral interventions to improve maternal outcomes for women in the United States at high risk for adverse pregnancy outcomes.medRxiv : the preprint server for health sciences · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWomen with elevated body mass index are encouraged to lose weight before pregnancy, but no trials have tested the effects of prepregnancy weight loss on health outcomes.
objectiveThis study aimed to determine whether prepregnancy weight loss reduces gestational weight gain and improves pregnancy outcomes. STUDY
designPragmatic randomized clinical trial was conducted between May 2015 and October 2019 at Kaiser Permanente Northwest, an integrated health system. Data collection was blind to condition assignment. Eligible participants were women aged 18 to 40 years with a body mass index of ≥27 kg/m
resultsOf the 326 participants, 169 had singleton pregnancies lasting ≥14 weeks (analytical cohort: intervention, 89; control, 80). At baseline, mean age was 31.3±3.5 years, and body mass index was 34.8±5.8 kg/m
conclusionParticipation in the prepregnancy weight loss intervention had no effect on women's likelihood of exceeding gestational weight gain guidelines. Although the intervention group successfully lost weight before conception, the intervention group was associated with greater weight gain in late pregnancy. To effectively reduce weight throughout pregnancy and improve maternal and child outcomes, prepregnancy weight loss interventions may need to be combined with intensive weight management that continues throughout delivery.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.